In a recent published paper, Pourshanazari et al found that morphine enhanced angiogenesis in murine matrigel method in sham and two-kidney one-clip (2K-1C) hypertensive animals and they concluded that this effect is via NO pathway (1). Morphine acts both directly and indirectly on angiogenesis, however, the results are contradictory. It seems that the different effect of morphine on angiogenes...

BACKGROUND Oral mucositis is the dose-limiting toxicity for patients receiving concurrent chemoradiotherapy regimens for tumors of the head and neck area. Currently, the management of established mucositis includes the use of topical anesthetics and systemic analgesics. Based on the clinical evidence of pain alleviation by topical morphine in patients with some inflammatory and painful conditio...

Background . The therapy of chronic pain in cancer patients is a highly topical issue for the modern health care system. Intense syndrome involves prescription strong opioid analgesics (ОА), most which are classified as narcotic drugs and under strict governmental control. In this situation, increasing use that equivalent dosages to morphine do not require special drug may increase availability...

Topically applied opioids have provided effective analgesia without adverse effects, including tolerance, in adult patients with painful inflammatory conditions. The presumed mechanism of action is by interaction with opioid receptors which are sited on sensory nerve terminals and which may be up-regulated in inflammation. The use of peripherally acting opioids has not been studied in paediatri...

We have investigated whether neurons in superficial laminae of the spinal dorsal horn respond to intracutaneous (ic) delivery of histamine and other irritant chemicals, and thus might be involved in signaling sensations of itch or chemogenic pain. Single-unit recordings were made from superficial lumbar dorsal horn neurons in pentobarbital sodium-anesthetized rats. Chemoresponsive units were id...

Recent research suggests that opioid receptors on peripheral nerve terminals may play an important role in the modulation of pain. Clinical applications of this knowledge have been rather slow to evolve. We describe a consecutive series of nine patients with painful skin ulcers due to a variety of medical conditions. All patients were treated with a topical morphine-infused gel dressing. Seven ...

clinical studies suggest that essential oil of eugenia caryophyllata (clove) buds (eoec) is efficacious in the treatment of dental pain. in the present study, we investigated the analgesic and local anesthetic effects of eoec and its possible mechanisms of action in acute corneal pain in rats. eoec was extracted by hydro-distillation in a clevenger type apparatus from clove buds. the acute corn...