The antifungal activities of several solanum alkaloids and their derivatives were examined against a variety of fungal strains such as Candida albicans and Trichophyton spp. Solacongestidine (I) showed the strongest activity (minimum inhibitory concentration) against C. albicans (0.8 ƒÊg/ml), T. rubrum (0.4 ƒÊg/ml) and Cryptococcus albidus (0.78 ƒÊg/ml), and also showed lesser activities agains...

α‑Tomatine is a glycoalkaloid that occurs naturally in tomatoes (Lycopersicon esculentum). In the present study, the effects of α‑tomatine on human myeloid leukemia HL‑60 cells were investigated. Treatment of HL‑60 cells with α‑tomatine resulted in growth inhibition and apoptosis in a concentration‑dependent manner. Tomatidine, the aglycone of tomatine had little effect on the growth and apopto...

and their glycosides are normally 22R configuration. On the other hand, spirosolanes such as tomatidine, solasodine and their glycosides take both 22R and 22S configurations (Chart 1). To determine the configuration at C-22 is very important, because the difference in C-22 configuration relates to the chemical reactions and bio-activity, for example, as shown in the following reaction of spiros...

The purpose of this study was to evaluate the antioxidant and antimicrobial properties of extracts of different fractions of two tomato plant cultivars. The stems, roots, leaves, and whole-plant fractions were evaluated. Tomatine and tomatidine were identified by HPLC-DAD. The leaf extracts from the two varieties showed the highest flavonoids, chlorophyll, carotenoids, and total phenolics conte...