Acinetobacter sp. Tol 5 exhibits an autoagglutinating nature and noteworthy adhesiveness to various abiotic surfaces from hydrophobic plastics to hydrophilic glass and stainless steel. Although previous studies have suggested that bacterionanofibers on Tol 5 cells are involved in the adhesive phenotype of Tol 5, the fiber that directly mediates Tol 5 adhesion has remained unknown. Here, we pres...

Toxicokinetic Modeling of the Combined Exposure to Toluene and n-Hexane in Rats and Humans: Nabeel ALI, et al. Département de médecine du travail et d’hygiène du milieu, Faculté de médecine, Université de Montréal—We studied the toxicokinetic fate of toluene (TOL) and n-hexane (HEX) in rats exposed to mixtures of these solvents by inhalation during 4 hours. We developed and validated a physiolo...

Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulators, which hold great promise in immunotherapy of autoimmune diseases. In this ...

In order to reduce the cesarean-delivery rate, more and more pregnant women are offered trials of labor (TOL) after their previous cesarean sections. TOL and elective repeat cesarean section (ERCS) have different risks and benefits. We constructed a decision analysis to explore this issue. Probabilities were derived from literature reviews. Health state utilities were derived from the authors' ...

Proteins of the Tol-Pal (Tol-OprL) system play a key role in the maintenance of outer membrane integrity and cell morphology in gram-negative bacteria. Here we describe an additional role for this system in the transport of various carbon sources across the cytoplasmic membrane. Growth of Pseudomonas putida tol-oprL mutant strains in minimal medium with glycerol, fructose, or arginine was impai...

The aim of this research was to improve our understanding of human toxicity due to exposure to DMF, MEK, or TOL individually as compared to exposure to DMF-MEK or DMF-TOL mixtures, by comparing EC50 values as well as the morphological changes in HepG2 cells treated with these substances. We found that there was marked cell necrosis in the groups treated with mixtures than in those treated with ...

The objective of the present study was to develop a physiologically based pharmacokinetic (PBPK) model for a ternary mixture of alkyl benzenes [toluene (TOL), m-xylene (XYL), and ethylbenzene (EBZ)] in rats and humans. The approach involved the development of the mixture PBPK model in the rat and extrapolation to humans by substituting rat physiological parameters and blood:air partition coeffi...

A study was performed in growing pigs to evaluate the efficacy of α-tocopherol (Tol) concentration in plasma, muscle, liver, and adipose tissue following dietary supplementation with vitamin E (VE) and various sources of fat. The trial involved 96 piglets weaned at an average of 28 d of age. Piglets were fed for 2 wk a semipurified diet not supplemented with VE. Piglets were then randomly assig...

Some executive tasks may require diverse abilities to solve, having implications for the comprehension of an individual’s performance. This study investigated the processes involved in the resolution of a complex test of executive function (EF): the Tower of London (ToL) task. One hundred twenty-four healthy teenagers, 11–14 years old (M = 12.5, SD = 1.14) participated in the study. They were t...

Setelah penggunaan Gardu Tol Otomatis (GTO) pada jalan tol, pekerjaan petugas untuk memasukkan data jenis kendaraan secara manual mesin transaksi mengeluarkan tarif tol sesuai dengan digantikan alat klasifikasi otomatis/ Automatic Vehicle Classification (AVC ). Alat AVC mengklasifikasikan otomatis kendaraan. Meskipun demikian, masih ditemukan kesalahan dalam ini ketika bergerak mundur setelah m...