The enzymatic activity of Bacillus subtilis glutamine synthetase (GS), which catalyzes the synthesis of glutamine from ammonium and glutamate, is regulated by glutamine feedback inhibition. The feedback-inhibited form of B. subtilis GS regulates the DNA-binding activities of the TnrA and GlnR nitrogen transcriptional factors. Bacterial GS proteins contain a flexible seven-residue loop, the Glu3...

CcpA-Mediated Catabolite Activation of the Bacillus subtilis ilv-leu Operon 1 and Its Negation by Either CodYor TnrA-Mediated Negative Regulation 2 3 4 Yasutaro Fujita*, Takenori Satomura, Shigeo Tojo, and Kazutake Hirooka 5 6 7 Department of Biotechnology, Faculty of Life Science and Biotechnology, Fukuyama 8 University, 985 Sanzo, Higashimura-cho, Fukuyama-shi, Hiroshima 729-0292, Japan 9 10 ...