Bioceramic scaffolds such as silicate bioceramics have been widely used for bone tissue engineering. However, their high degradation rate, low mechanical strength and surface instability are main challenges compromising their bioactivity and cytocompatibility which further negatively affect the cell growth and attachment. In this study, we have investigated the effects of silk fibroin coating o...

collagen is the major protein component of cartilage, bone, skin and connective tissue and constitutes the major part of the extracellular matrix. collagen type i has complex structural hierarchy, which consists of treepolypeptide α-chains wound together in a rod-like helical structure. collagen is an important biomaterial, finding many applications in the field of tissue engineering. it has be...

severe hepatic failure accounts for many deaths and raises medical costs each year worldwide. currently, liver transplantation is the most common therapeutic option for patients with end-stage chronic liver disease. due to decrease in the number of organ donors, many in need of transplantation continue to remain on the waiting list. hepatic tissue engineering is a step toward alleviating the ne...

the incidence of traumatic brain injury (tbi) are annually increasing, developed tissue engineering methods could represent the definite remedies for patients with strongly injured central nervous system and have a great effect in the public healthcare cost. the current clinical treatments in tbi display several limitations. furthermore, several therapies, coming from neural tissue engineering ...

objective: one of the major issues in bone tissue engineering is the design and fabrication of bioactive, bioresorbable porous 3d scaffolds capable of maintaining their structure and integrity over a predictable period of time. one such approach is the fabrication of composite scaffolds. methods: in this study we present fabrication and characterization of novel silk/bioglass-composite scaffold...

Objective(s): Fabrication of scaffolds with improved mechanical properties and favorable cellular compatibility is crucial for many tissue engineering applications. This study was aimed to improve mechanical and biological properties of polycaprolactone (PCL), which is a common biocompatible and biodegradable synthetic polymer in tissue engineering. Nanofibrillated chitosan (NC) was used as a n...

A wide range of materials and scaffolding fabrication methods for bone tissue engineering have beenexplored recently. Fiber reinforced polymers (FRP) system appears to be a suitable system. By the exclusiveuse of biocompatible or bio-absorbable polymers and fibers, novel generation of scaffolds for applicationsin tissue engineering can be prepared. Mulberry Silk as highlighted...

traumatic brain injury (tbi) is a common reason of brain tissue loss as a result of tumors, accidents, and surgeries. renewal of the brain parenchyma is restricted by many reasons such as inimical substances produced as the result of trauma and also inflammatory responses. a strong cascade of inflammatory responses begins as a result of tbi which include recalling peripheral leukocytes into the...

Nanofibrous scaffolds produced by electrospinning have attracted much attention, recently. Aligned and random nanofibrous scaffolds of poly (vinyl alcohol) (PVA), poly (ε-caprolactone) (PCL) and nanohydroxyapatite  (nHA) were fabricated by electrospinning method in this study. The composite nanofibrous scaffolds were subjected to detailed analysis. Morphological investigations revealed that the...

spinal cord injury (sci) results in the damage of motor and sensory pathways. the molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. regeneration of injured central nervous system (cns) is limited by damaged cell environment. biomaterial scaffolds can reconstruct injured cns tissue following sci by promoting the migratio...