endometriosis is a gynecologic disorder characterized by the presence of viable, extrauterine endometrial tissue, predominantly on the ovary and pelvic peritoneum (1-3). typical symptoms consist of pelvic pain, dysmenorrhea, and infertility (1, 2). this condition takes place only in women of menstrual age, can grow or bleed cyclically and may cause adhesions (1, 2). endometriosis represents a w...

The aim of this work was to study the morphology adhesion formation under influence ozone in experiment, as well development prediction criteria and methods for correcting increased children. Materials methods. Experimental studies were carried out on 36 rabbits «Shinshilla» with a body weight 0.7–1.2 kg., which 12 animals included control group, did not carry ozonation abdominal cavity. main g...

Endometriosis is characterised by the presence of endometrial tissue outside uterine cavity that responds to oestrogen and stimulates local inflammatory processes, adhesions, pelvic pain, infertility. The treatment endometriosis includes use medications videolaparoscopy for excision adhesions or lesions. Some complications are associated with videolaparoscopy, such as vascular, intestinal, urin...

The linker of nucleoskeleton and cytoskeleton (LINC) complex allows cells to actively control nuclear position by coupling the nucleus to the cytoplasmic cytoskeleton. Nuclear position responds to the formation of intercellular adhesions through coordination with the cytoskeleton, but it is not known whether this response impacts adhesion function. In this paper, we demonstrate that the LINC co...

Cell-matrix adhesions are essential for cell migration, tissue organization and differentiation, therefore playing central roles in embryonic development, remodeling and homeostasis of tissues and organs. Matrix adhesion-dependent signals cooperate with other pathways to regulate biological functions such as cell survival, cell proliferation, wound healing, and tumorigenesis. Cell migration and...

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis is accompanied by collagen crosslinking, ECM stiffening, and increased focal adhesions. Induction of collagen crosslinking stiffened the ECM, promoted focal adhesions, enhanced P...

Adhesions are a central mechanism by which cells mechanically interact with the surrounding extracellular matrix (ECM) and neighboring cells. In both cell-ECM and cell-cell adhesions, forces generated within the actin cytoskeleton are transmitted to the surrounding environment and are essential for numerous morphogenic processes. Despite differences in many molecular components that regulate ce...

The interrelationship between microtubules and the actin cytoskeleton in mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show that uncoupling of microtubules from integrin adhesions by depletion or displacement of KANK family proteins connecting the adhesion protein talin with microtubule tips led to disruption of podosomes and augmentation of focal adhesions, si...

To pilot the utility of an endoscopic robot for use in hysteroscopic myomectomy a porcine uterine tissue model. Previous work has demonstrated potential applications such as polpectomy, lysis intrauterine adhesions, and retained IUD removal. However, can present challenges due to dense leiomyomas, location within myometrium, significant vascularity. In this video, surgeon uses excise leiomyoma ...

OBJECTIVE To confirm the diagnosis of Asherman's syndrome in patients with scanty menses/amenorrhoea or infertility and to assess the effectiveness of hysteroscopy in the treatment of Asherman's syndrome. METHODS A hospital based descriptive study conducted on 20 patients presenting with amenorrhoea, oligomenorrhoea, or infertility from Jan 2004 to June 2005. They were selected after excludin...