نتایج جستجو برای: tim 1

تعداد نتایج: 2757937  

2013
Hyun-Bae Jie Jing Li Raghvendra Srivastava Robert L Ferris

Although T-cell immunoglobulin mucin 3 (TIM-3) does not contain inhibitory or death signaling motifs in its cytoplasmic domain, it has been proposed to be associated with T cell suppression and/or exhaustion. However, several lines of evidence suggest that TIM-3 can stimulate T cells as a costimulatory molecule by coupling Src family tyrosine kinase Fyn and the p85 phosphatidylinositol 3-kinase...

2010
Julien Fourcade Zhaojun Sun Mourad Benallaoua Philippe Guillaume Immanuel F. Luescher Cindy Sander John M. Kirkwood Vijay Kuchroo Hassane M. Zarour

The paradoxical coexistence of spontaneous tumor antigen-specific immune responses with progressive disease in cancer patients furthers the need to dissect the molecular pathways involved in tumor-induced T cell dysfunction. In patients with advanced melanoma, we have previously shown that the cancer-germline antigen NY-ESO-1 stimulates spontaneous NY-ESO-1-specific CD8(+) T cells that up-regul...

2012
Jean Lin Leo Chen Lawrence P Kane Terry Strom Wenxia Song Lawrence Kane

The interaction between T cells and APCs bearing cognate antigen results in the formation of an immunological synapse (IS). During this process, many receptors and signaling proteins segregate to regions proximal to the synapse. This protein movement is thought to influence T cell function. However, some proteins are transported away from the IS, which is controlled in part by ERM family protei...

ژورنال: مدیریت سلامت 2010
آزاده, فریدون, امیرحسینی, مازیار, حری, عباس, شمس اردکانی, محمدرضا, محمد حسن زاده, حافظ, ولی نژادی, علی,

Introduction: This research was aimed to analyze mapping scheme of Traditional Iranian Medicine (TIM) with structure of common language of meta- thesaurus and Semantic network Unified Medical System Language (UMLS). The domain, location and relation of TIM in the UMLS is designed, and recitation of location and proportion of the TIM’s concepts are provided. Methods: This is a triphasic research...

Journal: :International immunology 2007
Peter R Wilker John R Sedy Vadim Grigura Theresa L Murphy Kenneth M Murphy

The T cell Ig domain and mucin domain (TIM) proteins form a conserved family of transmembrane cell-surface glycoproteins expressed by a variety of tissues. Each TIM protein contains a single V-type Ig domain, a glycosylated mucin-like domain, a transmembrane domain and a cytoplasmic domain. TIM proteins recognize a diverse array of ligands, including H-ferritin, galectin-9 as well as other TIM ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Sheng Xiao Craig R Brooks Chen Zhu Chuan Wu Johanna M Sweere Sonia Petecka Ada Yeste Francisco J Quintana Takaharu Ichimura Raymond A Sobel Joseph V Bonventre Vijay K Kuchroo

Tim-1, a type I transmembrane glycoprotein, consists of an IgV domain and a mucin domain. The IgV domain is essential for binding Tim-1 to its ligands, but little is known about the role of the mucin domain, even though genetic association of TIM-1 with atopy/asthma has been linked to the length of mucin domain. We generated a Tim-1-mutant mouse (Tim-1(Δmucin)) in which the mucin domain was del...

2008
Tim Magnus Ying Liu Graham C. Parker Mahendra S. Rao

One con repair’. *Autho Stem Cell Section, Laboratory of Neurosciences, National Institute on Aging, NIH, 333 Cassell Drive, Room 406A, Baltimore, MD 21224, USA Children’s Research Center of Michigan, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children’s Hospital of Michigan, Detroit, MI 48201, USA Corporate Research Laboratories, Invitrogen Co...

Journal: :The Journal of clinical investigation 2010
Sanchaita Sriwal Sonar Yen-Ming Hsu Melanie Lynn Conrad Gerard R Majeau Ayse Kilic Ellen Garber Yan Gao Chioma Nwankwo Gundi Willer Jan C Dudda Hellen Kim Véronique Bailly Axel Pagenstecher Paul D Rennert Harald Renz

Studies in mice and humans have revealed that the T cell, immunoglobulin, mucin (TIM) genes are associated with several atopic diseases. TIM-1 is a type I membrane protein that is expressed on T cells upon stimulation and has been shown to modulate their activation. In addition to a recently described interaction with dendritic cells, TIM-1 has also been identified as a phosphatidylserine recog...

2013
Judith Leitner Armin Rieger Winfried F. Pickl Gerhard Zlabinger Katharina Grabmeier-Pfistershammer Peter Steinberger

T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and galectin-9 was described as a binding partner that mediates T cell inhibitory effects of TIM-3. Moreover, it was reported that like PD-1 the classical exhaustion marker, ...

Journal: :The Journal of clinical investigation 2008
Takuya Ueno Antje Habicht Michael R Clarkson Monica J Albin Kazuhiro Yamaura Olaf Boenisch Joyce Popoola Ying Wang Hideo Yagita Hisaya Akiba M Javeed Ansari Jaeseok Yang Laurence A Turka David M Rothstein Robert F Padera Nader Najafian Mohamed H Sayegh

T cell Ig mucin 1 (TIM-1) plays an important role in regulating immune responses in autoimmune and asthma models, and it is expressed on both Th1 and Th2 cells. Using an antagonistic TIM-1-specific antibody, we studied the role of TIM-1 in alloimmunity. A short course of TIM-1-specific antibody monotherapy prolonged survival of fully MHC-mismatched vascularized mouse cardiac allografts. This pr...

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