The lipolytic activity of bovine thyroid-stimulating hormone and its subunits have been compared to the lipolytic activity of ovine-luteinizing hormone and its subunits. When tested on white adipocytes isolated from epididymal fat pads of BALB/c mice, thyroid-stimulating hormone was a potent lipolytic agent, active at a concentration of 7 X lo-lo M. In contrast, the isolated subunits of thyroid...

The role of sympathetic innervation in regulation of thyroid function is incompletely understood. We, therefore, carried out studies in rats utilizing techniques of norepinephrine turnover to assess thyroid sympathetic activity in vivo. Thyroidal sympathetic activity was increased 95% by exposure to cold (4 degrees C), 42% by chronic ingestion of an iodine-deficient diet, and 32% in rats fed a ...

The production of H2O2, which is essential to thyroid hormone synthesis, involves two NADPH oxidases: dual oxidases 1 and 2 (DuOx1 and DuOx2). A functional study with human DuOx genes and their 5'-flanking regions showed that DuOx1 and -2 promoters are different from thyroid-specific gene promoters. Furthermore, their transcriptional activities are not restricted to thyroid cells. While regulat...

the host thyroid. The tumors themselves showed extremely low incorporation, although thyroidectomy of the host significantly increased the incorporation in the tumors. However, results of incorporation experiments do not distinguish the transitional from the autonomous tumors. Tumor growth also caused iodide peroxidase activity in the host thyroid to decline. The enzyme activity in the transiti...

Thyroid function is known to be affected by many commonly used drugs of varied chemical structures. It is known that substances like sulphonamides, perchlorates, nitrates affect thyroid activity. With the introduction of radio active iodine in experimental and clinical medicine, it has been possible to study critically the effect of drugs on thyroid activity, on the ba-is of iodine uptake by th...

BACKGROUND This Case Conference reviews the normal changes in thyroid activity that occur during pregnancy and the proper use of laboratory tests for the diagnosis of thyroid dysfunction in the pregnant patient. CASE A woman in the 18th week of pregnancy presented with tachycardia, increased blood pressure, severe vomiting, increased total and free thyroid hormone concentrations, a thyroid-st...

Introduction: Thyroid cancer is at the ninth from ten of common malignant cancer. A man has higher risk to get Thyroid cancer that a woman has. This organ is lain near human neck. The use of radioactive I-131, I-123 and Tc-99m for diagnosis of thyroid cancer has a risk where other organs around Thyroid will accept dose of radiation. One of the risks is large dose which is accep...

administration of a precise amount of activity in thyroid gland radioiodine (¹³¹i) therapy is of prime importance. several methods for this purpose have been suggested and used over many years. in this paper, a method for required ¹³¹i activity calculation for each case has been proposed. major factors affecting ¹³¹i calculation such as gland volume, integral dose, and prescription index have b...

In order to study the effects of a severe bacterial infection on thyroid function rats were subjected to group A streptococcal pneumonia, and thyroid activity determined by measurement of the rate of discharge of I(131) from the thyroid gland. Decreased thyroid activity of moderate to marked degree was observed in the majority of infected animals. Infected animals ate less than normal animals. ...

INVESTIGATIONS of seasonal changes in thyroid histology in wild birds have shown that increases in activity occur in the period preceding and during the annual molt (Davis and Davis, 1954; Assenmacher, 1958; Voitkevich, 1966) and in response to low temperature (Wilson and Farner, 1960; Kendeigh and Wallin, 1966). Involvement of th'e avian thyroid in migration and reproduction has also been sugg...