Ethanolic extract of Curcuma xanthorrhiza was used to evaluate the analgesic and toxicity effects in vivo. The extract was standardized using GC-MS, which showed that 1 mg of Curcuma xanthorrhiza ethanolic extract contains 0.1238 mg of xanthorrhizol. The analgesic activity was studied in rats using three different models, namely the hot plate test, tail flick test and formalin-induced pain test...

introduction: nucleus cuneiformis (ncf), as part of descending pain inhibitory system, cooperates with periaqueductal gray (pag) and rostral ventromedial medulla (rvm) in supraspinal modulation of pain. cannabinoids have analgesic effects in the pag, rvm and ncf. the transient receptor potential vanilloid type 1(trpv1) can be activated by anandamide and win55,212-2 as a cannabinoid receptor ago...

extracts obtained from the petals of rosa damascena (rosaceae) are used in iranian folk medicine as remedies for the treatment of some inflammatory diseases. in this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-inflammatory and analgesic activities. the extract was administered at the doses (p.o.) of 250, 500 and 1000?mg/kg and the dose...

objective(s) the present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. materials and methods antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. results promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhi...

  The paragigantocellularis (PGi) nucleus constitutes a large portion of the ventral pontomedullary reticular formation. Neurons within the PGi have been implicated in a variety of functions including cardiovascular regulation, respiratory control, pain and analgesia. Investigators have demonstrated that electrical stimulation and microinjection of L-glutamate into the PGi produce antinocicepti...

The efficacy of some aminoadamantane derivatives used as neurodegeneration treatments is due to their ability to block NMDA receptors. But this mechanism of pharmacological action can also produce analgesic activity. Analgesic properties of two aminoadamantanes, amantadine (20 mg/kg) and hemantane (20 mg/kg), which were uncompetitive NMDA receptor antagonists, were assessed in rodent models of ...

platanus orientalis l. (platanaceae) is a medicinal tree used in iranian folklore and traditional medicine as a pain and inflammation reliever. in this study, the polyphenolic and total extract of p. orientalis leaves were prepared and their antinociceptive effects were studied in mice using the acetic acid-induced writhing, formalin and light tail flick tests. both hydroalcoholic and polypheno...

  There are several reports on the therapeutic effects of TFG in Iranian traditional medical literature such as antinociceptive, antipyretic, and anti-inflammatory, antidiabetic and antidiuretic effects. The anti-inflammatory and anti-pyretic effects of TFG have been confirmed in experimental models. In the present study, the antinociceptive effect of TFG extract in formalin and tail flick test...

Introduction: Nucleus cuneiformis (NCF), as part of descending pain inhibitory system, cooperates with periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) in supraspinal modulation of pain. Cannabinoids have analgesic effects in the PAG, RVM and NCF. The transient receptor potential vanilloid type 1(TRPV1) can be activated by anandamide and WIN55,212-2 as a cannabinoid receptor ago...

Effect of four calcium channel blockers (CCBs) belonging to different chemical classes, alone and in combination with morphine was investigated on two models of pain sensitivity, i.e. formalin and tail flick tests in mice. All the studied CCBs, i.e. diltiazem, flunarizine, nimodipine and verapamil inhibited formalin-induced pain responses; however, with verapamil, though there was a trend towar...