OBJECTIVES To evaluate the risk of venous thromboembolic events associated with the use of progestin-only contraception and whether that risk differs with the mode of drug delivery (oral, intrauterine, or depot injection). DESIGN Systematic review and meta-analysis of randomised controlled trials and observational studies. DATA SOURCES Pubmed, Embase, Cochrane Library, and reference lists o...

BACKGROUND Several acute complications related to takotsubo cardiomyopathy (TTC) have been documented recently. However, the incidence and clinical significance of acute thromboembolic events in TTC is not well established. METHODS A detailed investigation of the clinical characteristics and in-hospital complications of 114 consecutive patients diagnosed with TTC between January 2003 and Sept...

Background: There is significant evidence to support that patients with the Coronavirus disease 2019 (COVID-19) have a higher propensity develop thrombotic events. COVID-19 in intensive care units (ICU) an increased rate of venous thromboembolism (VTE), ranging from 17% 25%. Apart acute respiratory failure, coagulopathy remains common abnormality these patients, within creased levels both fibri...

Department of Medical Oncology, Institute of Cardiovascular Research VUMC, University of Amsterdam Postbus 7057, 1007 MB Amsterdam (The Netherlands) Tel. 31 204444 373, Fax 31 204444 355, E-Mail [email protected] Our department participated in multi-center phase II trials investigating the efficacy and toxicity of the angiogenesis inhibitor SU5416 in patients with advanced renal cell carcinoma, ...

In the USA, and worldwide, acute venous thromboembolism remains a major cause of morbidity and mortality. It is estimated that 600,000 episodes of acute pulmonary embolism occur each year in the USA that result in 50,000±100,000 deaths [1]. Despite the magnitude of the disease and extensive investigative efforts into its pathogenesis, diagnosis and therapy over the last four decades (1960±2000)...

conclusions this case inspires consideration of hiv infection as a leading cause of thromboembolic event in individuals affected by the first episode of unprovoked one in whom diagnosis of hiv infection has not been established yet. case presentation a 27-year-old heterosexual smoker man was referred to our center due to a sudden-onset severe left lower extremity pain and claudication since thr...

BACKGROUND We investigated changes in the International Normalized Ratio (INR) and its measurement interval in patients with thromboembolic events who were treated by low intensity anticoagulation therapy after isolated mechanical aortic valve replacement. MATERIALS AND METHODS Seventy-seven patients who underwent surgery from June 1990 to September 2006 were enrolled in the study and observe...

BACKGROUND Patients with a patent foramen ovale (PFO) and paradoxical embolism are at risk for recurrent thromboembolic events. This study investigated the long-term risk of recurrent thromboembolic events in patients with PFO and paradoxical embolism after percutaneous PFO closure. METHODS AND RESULTS Since 1994, a total of 80 patients with PFO and at least 1 paradoxical embolic event (trans...