OBJECTIVE To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls. DESIGN Cohort study of outpatients using administrative data. SETTING 3 US Medicaid programmes. PARTICIPANTS Patients with schizophrenia treated with clozapine, haloperidol, risperidone, or thioridazine; a control group of patients with glau...

background: toxoplasma gondii is the most common parasite causing latent cerebral infections in human. it has been shown that some anti-psychotic drugs are able to inhibit the proliferation of the parasite in in vitro study. there is very limited data regarding the inhibitory effect of anti-psychotics on toxoplasma in in vivo . in this study, we evaluated anti- toxoplasma activity of fluphenazi...

Uses ■ Psychotic Disorders Thioridazine is used for the symptomatic management of psychotic disorders. However, because thioridazine has the potential for substantial, and possibly life-threatening, proarrhythmic effects and can precipitate sudden death, use of the drug is reserved for patients with schizophrenia whose disease fails to respond adequately to appropriate courses with at least 2 d...

Tumor metastasis is the most common cause of death and poor prognosis for cancer patients. Therapeutics that prevent tumor metastasis are the key to prolonging the lifespan of cancer patients. Cancer stem cells are believed to be critical in the metastatic process. Recently, drug screening for cancer stem cells reports that antipsychotic drugs displayed potential anticancer activity. Thioridazi...

We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). S...

Thioridazine toxicity has been described as a 'progressive chorioretinopathy', but this designation can be misleading. During the first year after thioridazine exposure retinal pigmentation evolves from a granular to a patchy or nummular appearance. However, visual function and the electroretinogram typically improve during this period. Some cases may show chorioretinal atrophy and functional l...

We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the "Denver regimen" against...