Metastatic bone disease is a serious clinical complication for the treatment of patients with advanced cancer, but few therapeutic options are currently available. Bisphosphonates are an established standard care for these patients, but new treatments are now emerging, including the use of monoclonal antibodies targeting the RANK ligand. In this issue of the BJP, Reuter et al. provide evidence ...

Introduction: Overuse of muscles, stress and dehydration are some the reasons for muscle spasms. Muscle cramps often resolve on their own but in cases medical intervention is required. Aim: The aim this article to study modulating activity using GABA inhibitors. Materials Methods: Treatment plans bruxism include different ways activity, which should be studied. Results: A spasm an involuntary, ...

OBJECTIVE Aim of the present work is to assess the effectiveness of a scientific protocol built up to relieve pain in chronic temporo-mandibular disorders (TMD) using Michigan splint together with a pharmacological therapy compared to the traditional occlusal therapy by Michigan splint alone. PATIENTS 35 adult patients, with signs and symptoms of TMD lasting more than 6 months, were enrolled ...

A simple, specific, accurate, precise and reproducible method has been developed and validated for the simultaneous estimation of Thiocolchicoside and Diclofenac in pharmaceutical formulation by UV-Spectrophotometric method which includes Simultaneous Equation method (Method I), Absorbance Correction method (Method II). For development of Method I, wavelengths were selected 260.0 nm λmax for th...

The R/Bioconductor package, TCC, provides users with a robust and accurate framework to perform differential expression (DE) analysis of tag count data. We recently developed a multi-step normalization method (TbT; Kadota et al., 2012 [3]) for two-group RNA-seq data. The strategy (called DEGES) is to remove data that are potential differentially expressed genes (DEGs) before performing the data...