نتایج جستجو برای: thiazolo 3
تعداد نتایج: 1811556 فیلتر نتایج به سال:
The present review covers the recent synthetic strategies and chemical transformations of thiazolo[3,2-a]benzimidazoles and it also presents the highlights of the biological activities of these compounds.
This study describes asymmetric Mannich-type additions between C-5 lithiated thiazolo[3,2-b][1,2,4]triazoles and enantiomerically pure (SS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine. Under the optimized conditions, these reactions proceed with good (up to 78%) chemical yields and virtually complete (98 : 2 to >99 : 1 dr) diastereoselectivity. The same stereochemical outcome was obtain...
Transformation of 3-propargylmercapto-6 methyl-1, 2,4-triazin- 5 (2H)- one (1; R=CH3) to 3,6- dimethyl-7H- thiazolo [3,2-b] [1, 2, 4] triazin -7- one (2) is performed under basic condition. The formation of (2) may be mainly due to the high reactivity of acetylenes towards nucleophiles and isomerization of the intermediate.
In order to develop a better bioactive molecules with good efficacy, we synthesized a new series of Thiazolo [3,2-a] pyrimidine derivatives with good yield and studied their anthelmintic properties, structureactivity relationships (SARs). A new series of Thiazolo[3,2-a]pyrimidines have been synthesized through duff formylation, ‘One pot’ Biginelli reaction, cyclization followed by knoevenagel c...
In our efforts to address the rising incidence of hepatocellular carcinoma (HCC), we have made a commitment to the synthesis of novel molecules to combat Hep-G2 cells. A facile and highly efficient one-pot, multicomponent reaction has been successfully devised utilizing a p-toluenesulfonic acid (p-TSA)-catalyzed domino Knoevenagel/Michael/intramolecular cyclization approach for the synthesis of...
Synthesis, Characterization and Biological Activity of Various Substituted Benzothiazole Derivatives
A series of 2-(benzo[d]thiazol-2-ylthio)-N-(2-oxoindolin-3-ylidene)acetohydrazide (3a3g), 2-(benzo [d]thiazol-2-ylthio)-N-(2,4’-dioxospiro[indolin-3,2’-thiazolidin)-3’yl)acetamide (4a-4g) and 2'-((benzo[d]thiazol-2-ylthio)methyl)spiro[indoline-3,5'thiazolo[4,3-b][1,3,4]oxadiazol]-2-ones (5a-5g) have been synthesized and screened for their anti-inflammatory, analgesic and antibacterial activitie...
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