A respiratory monitoring system based on a quartz crystal microbalance (QCM) sensor with a functional film was designed and investigated. Porphyrins 5,10,15,20-tetrakis-(4-sulfophenyl)-21H,23H-porphine (TSPP) and 5,10,15,20-tetrakis-(4-sulfophenyl)-21H, 23H-porphine manganese (III) chloride (MnTSPP) used as sensitive elements were assembled with a poly(diallyldimethyl ammonium chloride) (PDDA)....

It is demonstrated that even unsubstituted cationic ligands, namely the known diazoniadibenzochrysenes (, ) and the so far unreported tetraazoniapentaphenopentaphene (), stabilize quadruplex DNA upon association; the ligand exhibits essentially the same affinity towards the quadruplex as does 5,10,15,20-tetrakis(1-methyl-4-pyridyl)-21H,23H-porphine, however, with a significantly higher selectiv...

The treatment of cis-[PtCl2(XylNC)2] with thiazol-2-amines in a 2:1 ratio leads to regioisomeric mixture two binuclear complexes. These regioisomers are products kinetic and thermodynamic control capable regioisomerization. When the same reaction is carried out 5-fold excess thiazol-2-amine, nucleophile able react situ-formed platinum(II) complexes, yielding new type bis-carbene platinum specie...

In a search for new leads towards potent antibacterial agents, an array of novel N-[2-(3 ́chloro-2 ́-oxo-4 ́-substitutedaryl-1-azetidinyl)-1-3-thiazol-4-yl]diphenylamine 4(a-e) and N-[2-(2 ́substitutedaryl-4 ́-oxo-1 ́3 ́-thiazolidin-3 ́-yl)-1,3-thiazol-4-yl]diphenylamine 5(a-e) have been synthesized from N-(2-substitutedbenzylidenylimino-1,3-thiazol-4-yl)diphenylamine 3(a-e). Structure of all the synth...

X-Ray analyses of free base, zinc, and nickel complexes of 2,3;7,8;12,13;17,18-tetrakis(6,13-dihydro-6,13-pentaceno)-21H,23H-porphine revealed that the porphyrin chromophores adopted a heavily-saddled conformation by interlocking of the biconcave porphyrins in the crystals containing halobenzenes as crystalline solvents, while the ring was almost flat in the crystals obtained from benzene or fr...

Studies with tritiated isotopes of glucose have demonstrated that hyperglycemia per se stimulates glucose utilization and suppresses glucose production in humans. These conclusions rely on the assumption that tritiated glucose provides an accurate measure of glucose turnover. However, if in the presence of hyperglycemia the isotope either loses its label during "futile" cycling or retains its l...

Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics. We present here the synthesis of new thiazol-2-(3H)-ones as an elaboration of potent HNE inhibitors with an isoxazol-5-(2H)-o...

Tripodal pyrrole imine and amide ligands provide platforms for combined primary and secondary coordination sphere interactions in square planar Pd and Cu, and octahedral Ti complexes.