Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, capable inhibiting cell adhesion to extracellular matrix (ECM). This functional site usually buried within molecular structure FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 induce a change in β1-integrin active inactive form, c...

Erythropoietin (EPO) exerts its effect on erythroid lineage cells through interaction with the EPO receptor (EPOR), so-called canonical pathway, and a complex consisting of EPOR common cytokine beta subunit (CD131) – non-canonical pathway for non-hematopoietic human animal body. realizes effects launch signaling cascade, which begins phosphorylation Janus kinase 2 (JAK2) then involvement phosphat...