glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (ms) and other autoimmune inflammatory cns disorders. n‑methyl‑d‑aspartate (nmda) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. current treatment approaches targeting glutamate exc...

goldfish carassius auratus were subjected to either formalin (250 ppm) or nacl (10 ppt), over a 0.5-h period followed by 24-h freshwater exposure. serum biochemistry was monitored before exposure (0), immediately after (0.5) plus 3 and 24 h after exposure. results showed that both formalin and nacl treatments caused rapid increase in cortisol with a peak at 3 h, which did not recover until 24 h...

The interaction of an intense laser pulse with large s,100 Åd clusters present in pulsed gas jets is shown to produce novel plasmas with electron temperatures far in excess of that predicted by abovethreshold ionization theory. The enhanced absorption of the laser light by the dense clusters results in the production of high ion charge states via collisional ionization resulting in strong x-ray...

Likewise, ongoing light ions therapy projects in Europe are based on a strong radiobiological rationale, supported by the preliminary clinical results from NIRS and GSI that tend to confirm the hypothesis of the expected therapeutic gain using High LET particles for radio-resistant tumors [2-4]. However, long-term results in prospective studies are still mandatory to assess the magnitude of the...

BACKGROUND Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents. RESULTS In th...

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We explore how nuclear modifications to the nucleon structure functions, shadowing, affect massive gauge boson production in heavy ion collisions at different impact parameters. We assume that the nuclear modifications are proportional to the local nuclear density. We calculate the dependence of Z, W and W production on rapidity and impact parameter in Pb+Pb collisions at 5.5 TeV/nucleon to stu...

Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. Chelation therapy could provide a valuable therapeutic approach to such disease states, since metals, particularly iron, are realistic pharmacological targets ...

Metal dyshomeostasis is involved in several pathologies, making metal ions promising therapeutic targets. Conjugating 8-hydroxyquinolines with sugars gave rise to novel derivatives with improved solubility, selectivity, and multifunctionality. Biological evaluation of these compounds suggests they have potential as therapeutic agents in diseases related to metal dyshomeostasis.