In patients with advanced cancer, a readiness to address pain and other intolerable symptoms is a medical and moral imperative [1]. This has been described by Roy as the ‘emancipation principle of palliative care’ which states: ‘(one should) spare no scientific or clinical effort to free dying persons from twisting and racking pain that invades, dominates, and shrivels their consciousness, that...

Pharmacogenetics is the study of inherited variation in drug response. The goal of pharmacogenetics is to develop novel ways of maximizing drug efficacy and minimizing toxicity for individual patients. Personalized medicine has the potential to allow for a patient's genetic information to predict optimal dosage for a drug with a narrow therapeutic index, to select the most appropriate pharmacol...

BACKGROUND Oncology has lagged in CPOE adoption due to the narrow therapeutic index of chemotherapy drugs, individualized dosing based on weight and height, regimen complexity, and workflows that include hard stops where safety checks are performed and documented. OBJECTIVES We sought to establish CPOE for chemotherapy ordering and administration in an academic teaching institution using a co...

background and aims: sea buckthorn (hippophae rhamnoides l.) is a deciduous plant and has highly variable type and size, from small shrubs to medium-sized trees, traditionally growing in tibet and currently all over the world especially in europe and asia. this study aimed to overview some of therapeutic and non-therapeutic properties of sbt and its potential benefits and side effects in order ...

Stereotactic ablative radiotherapy (SABR) is an addition to the armamentarium against cancer. The technical requirements for SABR are very stringent, given its very narrow therapeutic window. However, when the principles are strictly followed, it is possible to deliver SABR to extracranial tumours safely and effectively.

Received 06 July 2012, Revised 15 December 2012, Accepted 16 December 2012 -------------------------------------------------------------------------------------------------------------------------------------------Abstract The study focuses on the interaction between morin and Tin(II) and the resulting complex was characterized through various analytical techniques by comparing it with morin. T...

There are currently no effective treatments for controlling the cough response with an acceptable therapeutic ratio. However, several new mechanisms have been identified which may lead to the development of new drugs.