Attachment of the prenyl groups farnesyl and geranylgeranyl to specific eukaryotic cell proteins by protein prenyltransferases is required for the functioning of a number of cellular processes including signal transduction. In this study it was found that previously reported inhibitors of mammalian protein farnesyltransferase (PFT) [those that mimic the substrate farnesyl pyrophosphate and thos...

32 33 Marine plankton ecosystems are an important component of biogeochemical cycling in the oceans. 34 Operational plankton functional type (PFT) models, that group plankton according to their 35 biogeochemical properties, are currently being developed to resolve biogenic gas exchange between 36 the ocean and atmosphere, and to model the lowest trophic levels in fisheries models. A 37 fundamen...

STUDY OBJECTIVES To compare the accuracy of virtual bronchoscopy (VB) with fiberoptic bronchoscopy (FOB) and pulmonary function testing (PFT) for the assessment of tracheal stenosis and bronchial anastomotic stenosis. DESIGN Prospective case series. SETTING Pulmonary institute of major tertiary university-affiliated center. PATIENTS The study group included 10 lung transplant recipients a...

Heat shock protein (HSP) 70 is aberrantly expressed in different malignancies and has emerged as a promising new target for anticancer therapy. Here, we analyzed the in vitro antileukemic effects of pifithrin-μ (PFT-μ), an inhibitor of inducible HSP70, in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cell lines, as well as in primary AML blasts. PFT-μ significantly inhibit...

Iraq has used extensively chemical warfare agents in recent Iran-Iraq conflict (1980-1988) and it is believed about 450,000 people were exposed to this agents. Long-term effects of chemical warfare agents, particularly mustard gas, on pulmonary function tests (PFT) (VC, FEV1 , FVC, FEV/FVC, PEF, MEF50%, MEF25%, MEF25-75% , ERC and IC) are estimated during 7.7 [standard deviation (SD)=l.2] years...

Plant functional type (PFT) distributions affect the results of biogenic emission modeling as well as O3 and particulate matter (PM) simulations using chemistrytransport models (CTMs). This paper analyzes the variations of both surface biogenic volatile organic compound (BVOC) emissions and O3 concentrations due to changes in the PFT distributions in the Seoul Metropolitan Areas, Korea. The Fif...

kashajam mahmood-ebne-hosein is one of the poets of second era in abbasi age. at first he worked as a cook in the court and then becamed famous as a poet and literary man by abi elhija hamdani .then by his son seif-ol-dole hamdani got attracted to egypt during his traveling. several books are remained after him such as a book of poem in which eulogy and description attained perfection.kashajam ...

This paper evaluates different strategies for enhancing (partial) fault tolerance (PFT) of feedforward artificial neural networks (ANNs). We evaluate a continuum of strategies between the two extremes (i) Replicating a minimal seed network to achieve a final desired size with the resultant PFT and (ii) Starting with the desired (larger) size but using modified training algorithms to achieve hig...

The aim of this study was to investigate the impact of a reported p53 inhibitor, pifithrin-α (PFT-α), on preimplantation porcine in vitro fertilized (IVF) embryo development in culture. Treatment of PFT-α was administered at both early (0 to 48 hpi), and later stages (48 to 168 hpi) of preimplantation development, and its impact upon the expression of five genes related to apoptosis (p53, bak, ...

BACKGROUND Personal fitness trackers (PFT) have substantial potential to improve healthcare. OBJECTIVE To quantify and characterize early adopters who shared their PFT data with providers. METHODS We used bivariate statistics and logistic regression to compare patients who shared any PFT data vs. patients who did not. RESULTS A patient portal was used to invite 79,953 registered portal us...