RATIONALE The E2F pathway plays a critical role in cardiac growth and development, yet its role in cardiac metabolism remains to be defined. Metabolic changes play important roles in human heart failure and studies imply the ketogenic enzyme β-hydroxybutyrate dehydrogenase I (BDH1) is a potential biomarker. OBJECTIVE To define the role of the E2F pathway in cardiac metabolism and dilated card...

PURPOSE Model-baseddose calculations (MBDCs) are performed using patient computed tomography (CT) data for patients treated with intraoperative125 I lung brachytherapy at the Mayo Clinic Rochester. Various metallic artifact correction and tissue assignment schemes are considered and their effects on dose distributions are studied. Dose distributions are compared to those calculated under TG-43 ...

The aim of this work is to evaluate the performance of a commercial brachytherapy treatment planning system (TPS) with TG-43 Vendors Input Data (VID), analyze possible discrepancies with respect to a proper reference source and its implications for standard treatments, and judge the effectiveness of certain widespread recommended quality controls to find potential errors related with the interp...

Background: Monte Carlo determination of TG-43 brachytherapy dosimetry parameters and dose distribution calculation for 131Cs source model CS-1 are presented in this study. Materials and Methods: The dose distribution was calculated around the 131Cs Model CS-1 located in the center of 30 cm ×30 cm ×30 cm water, and soft tissue phantoms cube using MCNP code by Monte Carlo method. The percentage ...

Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43). To investigate in depth the behavioral phenotype associated with this proteinopathy, we used as a model transgenic (Tg) mice conditionally overexpressing human wild-type TDP 43 protein (hTDP-43-WT) in foreb...

31 The role of cardiac myosin essential light chain (ELC) in the sarcomere length (SL)-dependency 32 of myofilament contractility is unknown. Therefore, mechanical and dynamic contractile 33 properties were measured at SL 1.9 μm and 2.2 μm in cardiac muscle fibers from two groups of 34 transgenic (Tg) mice: 1) Tg-wild type (WT) mice that expressed wild type human ventricular 35 ELC; and 2) Tg-Δ...