An efficient, novel bifunctional C2-symmetric ionic liquid–supported (S)-proline organocatalyst 7 was developed for a one-pot, five-component reaction involving ?-keto esters 8, aryl aldehydes 9, and amines 10, affording highly functionalized tetrahydropyridines 11a–o by simultaneous generation of fives bonds two stereogenic centers with extraordinary diastereo- enantioselectivities (up to >...

The reactivity of 6-(nitrophenyl or trimethoxyphenyl)-4-tert-butyldimethyl- siloxy-1,2,3,6-tetrahydropyridine derivatives with hydrazines under acid conditions is described. The structure of the products isolated - hydrazones, pyrazolines or pyridazinones - depended on the conditions used. In addition, a systematic study of the reaction outcomes was carried out by introducing variations on the ...

TiCl4/nano-cellulose as a biodegradable and eco-friendly Lewis acid catalyst was synthesized via reaction of nano-cellulose and TiCl4. This catalyst was characterized and used for synthesis of asymmetric highly functionalized tetrahydropyridines via a five-component condensation reaction of p-substituted anilines, aldehydes and ethyl acetoacetate under solvent-free condition. Simple methodology...