The crystal structure of the new diazatrioxa[9]circulene and tetrahydro-diazatetraoxa[10]circulene which represent first synthesized representatives “higher” hetero[n]circulenes with n>8, was analyzed in details. Hirshfeld surface analyses, d norm surfaces two-dimensional fingerprint plots were used to verify contributions different intermolecular interactions within tetrahydro-diazatetraoxa...

Five series of tetrahydrobenzothieno[2,3-d]pyrimidine and tetrahydrobenzothienotriazolopyrimidine derivatives have been synthesized namely: 4-(substituted amino)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidines 4a–d, 4-substituted (methylidenehydrazino)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidines 6a–c, 4-(3,5-disubstituted pyrazol-1-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine...

a quantitative structure-activity relationship (qsar) study was conducted for the prediction of inhibitory activity of 1-phenyl[2h]-tetrahydro-triazine-3-one analogues as inhibitors of 5-lipoxygenase. the inhibitory activities of the 1-phenyl[2h]-tetrahydro-triazine-3-one analogues modeled as a function of molecular structures using chemometrics methods such as multiple linear regression (mlr) ...

A one-pot condensation of isotryptamines and aldehydes that affords enantiomerically enriched 4-substituted tetrahydro-γ-carbolines is reported. The reaction is induced by a chiral thiourea/benzoic acid dual catalyst system. Purification of the N-Boc-protected products by trituration or crystallization provides the optically pure tetrahydro-γ-carboline derivatives in a scalable and highly pract...

Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.

Two new sulfated triterpenoid saponins, zygophylosides Q (1) and R (2), have been isolated from the barks of Zygophyllum fabago L. Their structures were elucidated as 3beta,24,28,30-tetrahydro-urs-20-ene-24-O-sulphonyl-3-O-[beta-D-glucopyranosyl]-30-O-beta-D-glucopyranoside and 3beta,24,28,30-tetrahydro-urs-20-ene-24-O-sulphonyl-3-O-[beta-D-xylopyranosyl]-30-O-beta-D-glucopyranoside, respective...

A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cyt...

In continuing studies of drugs against Mycobacterium leprae in mice we have tested the following compounds: lincomycin, clinimycin (7( S ) -chloro-7 -deoxylincomycin, clindamycin) , U-24729A (4' -pentylN -demethyl-7 -chlorolincomycin), amicetin, phosphonomycin, ABT-29666 (1-{3-[ 4-(pchlorophenyl-azo )-5, 6, 7, 8-tetrahydro-1naphthylamino] propyl} piperidine), ABT38396 (1{3-[ 4-( 6-methoxy-3-pyr...

The carcinogenicity of 1,11-dimethylchrysene (=5,7dimethylchrysene) and its 1,2,3,4-tetrahydro-, 3,4-dihydro-, and 1,2,3,4-tetrahydro-l-oxo derivatives was tested by mouse skin painting. Each mouse received 30 ¿/gof the chrysene on the dorsal skin twice weekly for one year, and the animals were observed for a second year. The 1-ketone was much more active than any of the hydrocarbons. Of the l...