OBJECTIVE To analyze the spectrum of testicular tumors in children in an unselected population-based series, as well as the results of testis-preserving surgery. PATIENTS AND METHODS Our hospital database was analyzed for operations for testicular tumors from 1981 to 2006. The clinical data and findings during follow up (4.7 years) were recorded. RESULTS Thirty-four patients were operated o...

Sertoli cell tumors of the testis are extremely rare tumors with a heterogeneous pathology. Three histological variants have been described: Sertoli cell tumor not otherwise specified (NOS), large cell calcifying sertoli cell tumor and the Sclerosing Sertoli cell tumor. The sclerosing Sertoli cell tumor described herein is associated with prominent stromal sclerosis. They present as painless...

A 22-year-old male presented at our institution with an incidentally ultrasound-detected testicular tumor. Magnetic resonance imaging showed a contrast-enhanced right intratesticular mass over 1 cm in size. The patient underwent testis sparing surgery. Pathologic examination revealed seminoma. A follow-up nine months later showed no residual tumor, a normal contour of the testis and no evidence...

Xanthogranulomatous orchitis has been reported to be an extremely rare inflammatory change caused by infection and is difficult to distinguish from testicular tumor. We report a 28-year-old man who presented with a lump in his left testis after a blunt testicular trauma. Based on a series of imaging tests, we suspected benign tumor such as epidermoid cyst and performed tumor enucleation (testis...

PURPOSE Cancer-testis antigens are promising targets for cancer immunotherapy. Identification of additional cancer-testis antigens with frequent expression in various cancers was attempted using representational differential analysis (RDA) and immunogenicity evaluation. EXPERIMENTAL DESIGN cDNAs preferentially expressed in testis were enriched using RDA by subtraction between testis and norma...

BACKGROUND Nuclear protein in testis carcinoma is a rare and very aggressive undifferentiated cancer which characteristically arises in the midline of the head, neck, and mediastinum. CASE PRESENTATION We describe the case of a 46-year-old white woman admitted for superior vena cava syndrome revealing a mediastinal tumor. Pathological examination of specimens obtained by mediastinoscopy revea...

herein we report a case of primary leiomyosarcoma of testis, which was believed to originate from normal testicular structures.  it contained smooth muscle cells, blood vessels and contractile cells of the seminiferous tubules.  no evidence of tumor spread was found. treatment consisted of orchiectomy with high ligation of the spermatic cord.  the patient received no adjuvant therapy and there ...

Alternative pre-messenger RNA (mRNA) splicing is a key molecular event that allows for protein diversity and plays important roles in development and disease. Alternative pre-mRNA splicing regulations during spermatogenesis and alternative pre-mRNA splicing etiology in testicular tumorigenesis are yet to be characterized. By genome-wide analysis, here we describe alternative splicing features t...

Abstract Background Adenomatoid tumor is a very rare benign neoplasm of mesothelial origin affecting mainly female and male genital tracts. The diagnosis challenging as this mimics many differential diagnoses. current literature offers only some case reports short series adenomatoid tumors. Case presentation A 47-year-old patient with unremarkable medical history presented for chronic mild pain...