background: the sertoli cells in the testis create unique and safe environment to protect seminiferous tubules from auto antigens and invading pathogens. these cells produce the survival factor of the blood-testis barrier and produce special materials such as androgen binding proteins and contribute to the coordinated action of spermatogenesis. given that the sertoli cells play an essential rol...

The Sertoli cell is a critical somatic that initiates the development of testicular morphology and determines important parameters for spermatogenic function. blood-testis barrier, also known as barrier one tightest tissue barriers in mammalian body, an immunological to separate post meiotic germ antigens from systemic circulation. Additionally, creating unique microenvironment spermatocytes ex...

Objective Diazinon is an organophosphate pesticide and today this pesticide is mostly used in agriculture. In this study, we analyzed the effects of diazinon and vitamin E on apoptosis and the proliferation of germ cells in rat testis. MaterialsAndMethods In this experimental study 30 male wistar rats, were divided into five groups (N=6). Control, sham (received olive oil), experimental group 1...

Background and Aims: This study aimed to observe the effect of Icariin on histomorphometric changes of testis and prostate induced by Acrylamide. Materials and Methods: Male mice were divided into four groups (n=8): A is the control group and does not get any treatment, B is the sham group and only received drinking water. C group received Acrylamide 10 mg/kg. D group received Acrylamide 15 mg...

background: to improve the athletic ability and muscle mass, anabolic androgenic steroids are abused by athletes. little is known about how these compounds affect the fine structures of the testis. this study aimed to identify the changes in the fine structure of testis following administration of nandrolone decanoate.   methods: twenty five sprague-dawley rats were randomly divided into two ex...

background:gossypol is a yellow toxic pigment from the cottonseed that can cause acute or chronic toxicity in humans and animals by affecting the testicular tissues. nowadays cottonseed is used as food supplement for ruminants specially the sheep. in this study, two different stem cell lines of testicular tissue including gc1-spg (mouse testis) and sftf-pi43 (sheep testis) cells were used to ev...

The ubiquitous isozyme of phosphoglycerate kinase, PGK-1, and the testis-specific isozyme, PGK-2, have been localized to specific cells of the testis by indirect immunofluorescence on Bouin’s fixed testis sections. The earliest cell of the spermatogenic series in which PGK-2 is detectable by immunofluorescence is the Stage 12 spermatid. The intensity of fluorescence increases as the spermatids ...