BACKGROUND Uro-oncological neoplasms have both a high incidence and mortality rate and are therefore a major public health problem. The aim of this study was to evaluate research activity in uro-oncology over the last decade. METHODS We searched MEDLINE and ClinicalTrials.gov systematically for studies on prostatic, urinary bladder, kidney, and testicular neoplasms. The increase in newly publ...

Epithelial cell adhesion molecule 1 (EpCAM) is an epithelial membrane glycoprotein, often used as a surrogate pan-epithelial marker. To compare the expression patterns of EpCAM and pankeratin antibody (CKpan), gold standard detection, tissue microarrays containing 11,053 samples from 101 different tumor types were analysed by immunohistochemistry. staining was detectable in 99 (82.5%) 120 tumou...

CONTEXT The medical treatment of advanced testicular germ cell tumors has changed over the past 30 years, with long-term survival now achieved in the majority of patients. Clinicians need to be familiar with the available treatment regimens for testicular cancer and their associated toxic effects. OBJECTIVE To review the treatments used for advanced testicular germ cell tumors and their assoc...

Testicular cancer is the most common solid organ tumor in young men and affects men during their reproductive years. Current therapeutic regimens have significantly improved survival but often adversely impact fertility. Understanding the effects of testicular cancer, the systemic effects of neoplasia, and the effects of treatment protocols, such as radiotherapy, chemotherapy, and retroperitone...

Sex-cord stromal tumours account for only about 6% of testicular neoplasms.' Leydig cell tumour is the commonest sub-type but other tissues that can be represented in varying amounts and degrees of differentiation include Sertoli, granulosa and theca-lutein elements. Testicular granulosa-cell tumour ofthe adult type is particularly uncommon. This report details a mixed sex-cord stromal tumour o...

Sir, It is well known that dermatomyositis (DM) is frequently associated with internal malignancy (1 ^ 2). Common malignant neoplasms found in association with DM are breast, lung, ovary, stomach and colon. Among such malignancies, testicular tumour appears to be rare and we found only one published case report of this combination (3). We report here a case of DM associated with a testicular tu...

Carcinoid tumours occur predominantly in the gastrointestinal tract and bronchial system of the lungs, but they can originate in less common anatomical sites such as the testes, which accounts for <1% of all testicular neoplasms. Carcinoid tumour is a rare and indolent neoplasm with the potential for distant metastasis. We report on a man with metastatic right testicular carcinoid tumour who ha...

Burned-out testicular tumor is a very rare clinical entity. There is no clinical finding in the testicle because it regresses spontaneously without any treatment and generally presents with metastases. Clinical examination of the testis and scrotal sonography are pivotal in the initial diagnosis of such neoplasms. We present a case of a 22-year-old male with hemoptysis, weight loss, and abdomin...

Tumours of the ovary accompanied by signs of masculinization (or defeminization) such as amenorrhea, hirsutism and enlargement of the clitoris are uncommon and there appears to be a great deal of confusion regarding their histogenesis. As some of these neoplasms histologically resemble testicular tissue, it is believed that they originate from remnants of the primitive sex cords or potentially ...

Germ cell tumors constitute the majority of all testicular tumors, which are relatively rare overall and are mainly encountered in young adults and teenagers. The term 'burnedout' germ cell tumor refers to the presence of a metastatic germ cell tumor with histological regression of the primary testicular lesion. Clinical examination of the testes and scrotal sonography is pivotal in the initial...