Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear receptor regulating adipogenesis, glucose homeostasis and inflammatory responses. The activity of PPARγ is controlled by post-translational modifications including SUMOylation and phosphorylation that affects its biological and molecular functions. Several important aspects of PPARγ SUMOylation including SUMO...

Metal-containing Schiff base/sulfoxides were developed as chiral ligands for Pd(II)-catalyzed asymmetric intramolecular allylic C–H amination reactions. The use of metal-containing base allows tuning the selectivity and reactivity Pd(II)-catalyst, whereby a base-Cu(II)/sulfoxide ligand in combination with Pd(OAc)2 showed best performance. Both internal terminal alkenes applicable, products obta...

In the crystal structure of the title compound, [Ru(3)(C(9)H(11)P)H(2)(C(18)H(15)P)(CO)(8)], the triangular Ru(3) unit is capped with one mesitylphosphin-idene ligand. In the trigonal-pyramidal Ru(3)P core, one Ru(II) atom is coordinated by a triphenyl-phosphane ligand in a terminal fashion. Two hydride ligands bridge over two Ru-Ru bonds. These Ru-Ru bonds [2.9400 (4) and 2.9432 (4) Å] are sli...

A new dinuclear gold(I) complex, possessing a bridging diphosphine ligand (1,2-bis(diphenylphosphino)ethane) and two terminal thiol ligands (1-thioglycerol), was synthesized fully characterized by IR, 1H 31P NMR, fluorescence, ESI-mass, diffuse reflection spectroscopy, together with X-ray diffraction elemental analyses. The compound formed 1D chain supramolecular structure through intermolecula...

Dinitrogen (N2) complexes of technetium (99Tc) are rare, and only two examples have been reported. To complement this important class also for 99Tc, different pincer-type 99Tc were studied to assess their abilities coordinating dinitrogen. The reactions the 99TcIII complex [99TcCl3(PPh3)2(NCCH3)] with pincer ligands PNPtBu PyrPNPtBu respectively gave [99Tc(PNPtBu)Cl2] [99Tc(PyrPNPtBu)Cl3], firs...

The anaerobic bacterium Chrysiogenes arsenatis respires using the oxyanion arsenate (AsO43–) as terminal electron acceptor, where it is reduced to arsenite (AsO33–) while concomitantly oxidizing various organic (e.g., acetate) donors. This respiratory activity catalyzed in periplasm of by enzyme reductase (Arr), with expression controlled a sensor histidine kinase (ArrS) and periplasmic-binding...

The bidentate phosphine ligand 1,2-bis(di-tert-butylphosphinomethyl)benzene (1,2-DTBPMB) has been reported over the years as being one of, if not the, best ligands for achieving alkoxycarbonylation of various unsaturated compounds. Bonded to palladium, provides basis first step in commercial (Alpha) production methyl methacrylate well very high selectivity linear esters and acids from terminal ...

The 39-kDa receptor-associated protein (RAP) is a molecular chaperone for the low density lipoprotein receptor-related protein (LRP), a large endocytic receptor that binds multiple ligands. The primary function of RAP has been defined as promotion of the correct folding of LRP, and prevention of premature interaction of ligands with LRP within the early secretory pathway. Previous examination o...