BACKGROUND Hydrochlorothiazide (HCT) is applied in the therapy of familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) caused by claudin-16 (CLDN16) mutation. However, the short-term efficacy of HCT to reduce hypercalciuria in FHHNC has not yet been demonstrated in a clinical trial. METHODS Four male and four female patients with FHHNC and CLDN16 mutation, under long-stan...

OBJECTIVE Previous studies indicate an increased short-term and long-term mortality from major cancer surgery performed towards the end of the working week or during the weekend. We hypothesised that the prognosis after major cancer surgery is also negatively influenced by surgery conducted during holiday periods. SETTING Population-based nationwide Swedish cohort study. PARTICIPANTS Patien...

BACKGROUND AND OBJECTIVES: This study aims down to evaluate the ability of chloride magnesium- aluminium- layered double hydroxides (4:1) for nitrate adsorption from the soil solution in successive cropping periods. METHODS: The study was conductedunder long-term cropping periods, including first crop): bell pepper; second crop: mentheae; third crop: cher...

BACKGROUND High rates of loss to follow-up (LTFU) are undermining rapidly expanding antiretroviral treatment (ART) services in sub-Saharan Africa. The intelligent dispensing of ART (iDART) is an open-source electronic pharmacy system that provides an efficient means of generating lists of patients who have failed to pick-up medication. We determined the duration of pharmacy delay that optimally...

OBJECTIVE(S) The present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (UCO) on the dorsal hippocampal neurons in rats. MATERIALS AND METHODS Sixty four male Sprague-Dawley rats aged 4 months were divided into two groups of sham and UCO. These two groups were further divided into 4 sets of histopa...

The distribution and abundance of neuropeptide-containing nerve fibers were examined in the carotid bodies of rats exposed to hypocapnic hypoxia (10% O2 in N2) for 2, 4, and 8 weeks. The carotid bodies after 2, 4, and 8 weeks of hypoxic exposure were enlarged by 1.2-1.5 times in the short axis, and 1.3-1.7 times in the long axis in comparison with the normoxic control ones. The enlarged carotid...

INTRODUCTION wheat bran has been known for many health benefits, but its glucose- and lipid-lowering activity still remains unresolved. OBJECTIVE to investigate effects of varying amounts of wheat bran and feeding period on serum glucose and lipids in sucrose-fed rats. METHODS eighty male Sprague-Dawley rats were assigned into 4 sucrose-based diets containing either 0, 5, 10 or 20% wheat br...

Previous studies have suggested that sympathetic sprouting in the periphery may contribute to the development and persistence of sympathetically maintained pain in animal models of neuropathic pain. In the present study, we examined changes in the cutaneous innervation in rats with a chronic constriction injury to the sciatic nerve. At several periods postinjury, hind paw skin was harvested and...