PURPOSE Symptoms such as nausea, vomiting, tightness of the chest, bradycardia, and shoulder or abdominal discomfort, caused by vagotonia occurring during uterus manipulation, have concerned healthcare professionals for some time. Patients sometimes report these symptoms when undergoing spinal anesthesia for cesarean sections (CSs). We designed a prospective, double-blind study to investigate t...

Objctive: The present study, investigates the analgesic effects and complications of intra-articular neostigmine, tramadol, tenoxicam and bupivacaine on postoperative pain in patients undergoing day case knee arthroscopy. Subjects: Group 1 received 0.5 mg neostigmine, Group 2 received 100 mg tramadol, Group 3 received 20 mg tenoxicam, Group 4 received 20 ml 0.5% bupivacaine (control) in 20 ml n...

JUSTIFICATIVA E OBJETIVOS: Existem controvérsias sobre o local de ação de opióides lipofílicos após injeção peridural, e alguns autores acreditam que esses fármacos agem no nível supra-espinhal, enquanto outros acham que ocorre ação espinhal. Para tentar esclarecer essa dúvida foi feito estudo comparativo da aplicação de fentanil por vias peridural e venosa após operações ortopédicas de membro ...

Aceclofenac (Almirall Prodesfarma SA) is an oral NSAID that is effective in the treatment of painful inflammatory diseases and has been used to treat > 75 million patients worldwide. It has proved as effective as diclofenac, naproxen and piroxicam in patients with osteoarthritis, diclofenac, ketorolac, tenoxicam and indomethacin in patients with rheumatoid arthritis and tenoxicam, naproxen and ...

We studied 32 patients undergoing bilateral symmetrical lower third molar surgery under general anaesthesia to determine if the combined effects of pre-emptive local anaesthetic block using 0.5% bupivacaine, together with i.v. tenoxicam and alfentanil had any benefits over postoperative administration. Patients acted as their own controls and were allocated randomly to have surgery start on one...

The effect of cyclodextrins on photodegradation of tenoxicam (TEN) was studied at pH 4, 7 and 10. After 60 min of irradiation with UV light, the photodegradation was extensive. All cyclodextrins (alpha, beta, or gamma) stabilize TEN and reduce the rate of photodegradation. The largest effect of cyclodextrins is at pH 7. Molecular modeling results help to explain and manipulate the results. The ...

We have compared the effect of peritonsillar infiltration with tenoxicam 5 mg and placebo on postoperative pain after tonsillectomy. Fifty patients undergoing bilateral elective tonsillectomy under general anaesthesia were allocated randomly to receive peritonsillar infiltration with tenoxicam 5 mg in 8 ml of normal saline (4 ml per tonsil) or normal saline only, before tracheal extubation. Med...

The treatment of pain before it initiates may prevent the persistent pain-induced changes in the central nervous system that amplify pain long after the initial stimulus. The effects of pre- or postoperative intraperitoneal administration of morphine (2 to 8 mg/kg), dipyrone (40 and 80 mg/kg), diclofenac (2 to 8 mg/kg), ketoprofen (10 and 20 mg/kg), and tenoxicam (10 and 20 mg/kg) were studied ...

Local forms of non-steroidal anti-inflammatory drugs (NSAIDs) are characterized by a high safety profile due to low systemic absorption. They do not increase the risk developing class-specific gastrointestinal, cardiovascular and kidney adverse events (AEs), which makes it possible prescribe them even in severe comorbid pathology, is typical for patients with osteoarthritis (OA). Objective : ev...