In recent years, considerable advances have been made in the field of regenerative medicine. Unlikeembryonic stem cells, which pose the problems of ethical concerns and cause severe immunological reactions as well as neoplasma formation after transplantation, umbilical cord blood is a primitive source ofmesenchymal stem cells that covers the benefits of both embryonic and adult stem cells. It h...

background: the present study was performed to investigate the effects of trace elements particularity se, zn and cu on tumor genesis in breast cancer. methods: the inhibitory effect of se, zn and cu, on telomerase activity was analyzed in human breast tumor tissues and breast cancer (t47d) cells. tissue specimens from 24 women with benign breast disease and 32 women with breast cancer specimen...

introduction: leukemia is a malignant disorder resulting from clonal proliferation of lymphoid or myeloid precursors with arrested maturation. it has been shown recently that telomers and telomerase activity are involved in the control of cell proliferation, regulation of cell senescence in the most somatic cells, and unlimited proliferation capacity of the malignant cells including leukemic ce...

objective(s):valproic acid (vpa), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. a relation between telomerase activity and resistance to apoptosis has been established. t...

in recent years, considerable advances have been made in the field of regenerative medicine. unlikeembryonic stem cells, which pose the problems of ethical concerns and cause severe immunological reactions as well as neoplasma formation after transplantation, umbilical cord blood is a primitive source ofmesenchymal stem cells that covers the benefits of both embryonic and adult stem cells. it h...

introduction: accumulating evidences indicated that during increasing of the animals' age, the number and the functional properties of hematopoietic stem cells (hscs) become altered because of a gradual decrease in replication potential.  the efficient factors in this process are dna damaging, reduced telomerase activity, shortening of telomeres and oxidative stresses. for overcoming these fact...

conclusions since telomerase is expressed in 90% of cancer cells, its inhibition can be considered as a goal of cancer treatment. results about 90% of cancers need a high level of this enzyme to continue cell multiplication. since this enzyme set is absent in normal cells, or present at a very low level, use of telomerase inhibitors cannot have significant effects on normal cells. evidence acqu...

There has been increasing interest in studying the effects of dietary factors on telomere length. The is a noncoding DNA sequence including "TTAGGG" at ends chromosomes vertebrates. stability length an important factor as survival signal for cells and cancer prevention. Telomerase multi-subunit polymerase that plays crucial role maintaining length, which critical age-related pathogenesis breast...