Twelve patients with familial amyloidosis with polyneuropathy were examined both by cross sectional echocardiography and by technetium-99m pyrophosphate scintigraphy to assess involvement of the heart non-invasively. All 12 patients had echocardiographic abnormalities. The most prominent findings were highly refractile myocardial echoes, thickened heart valves, and increased thickness of the he...

objective(s): in this study, we aimed to analyze the relationship between the diagnostic ability of fused single photon emission computed tomography/computed tomography (spect/ct) images in localization of parathyroid lesions and the size of adenomas or hyperplastic glands. methods: five patients with primary hyperparathyroidism (phpt) and 4 patients with secondary hyperparathyroidism (shpt) we...

introduction: the radioimmunoscintigraphy (ris) has found widespread clinical applications in  tumor  diagnosis.  human  epithelial  mucin,  muc1,  is  commonly  over  expressed  in  adenocarcinoma including 80% of breast cancers and represents a useful target for ris. the pr81  is  a  new  murine  anti-muc1  monoclonal  antibody  that  was  found  to  react  with  the  membrane  extracts of se...

Facticious accumulation of the radiopharmaceutical in the urinary draining system as shown by routine renal tests, like technetium- 99m-diethylenetriamine pentacetic acid, technetium-99m-mercaptylacetyltriglycine or technetium-99m-glucoheptonate renograms can be re-evaluated by administering a diuretic, like furosemide (FS) and obtaining post FS dynamic and static images. Urinary tract obstruct...

Askin tumor is a rare disease which had previously been reported as being thallium-201 and gallium-67 avid. Varying data regarding 18F- fluorodeoxyglucose metabolism has been described with Ewing family of soft tissue tumors. In this case, we present a patient found to have an Askin tumor of the left chest wall which demonstrated indium-111 pentetreotide and technetium-99m MIBI avidity. The les...

Sternal non-union is a severe complication of sternotomy closure following open heart surgeries. Healing problems typically occur in 0.3% to 5% of patients. Technetium-99m methylene diphosphonate (99mTc-MDP) bone scintigraphy has been used to assess bone nonunion to predict the healing response for proper management.  In this report, we present the case of a marked sternal nonunio...

The trifluoroacetyl group protects the nucleophilic HYNIC from unwanted side reactions yet allows radiolabelling with technetium-99m under mild conditions, due to efficient and specific promotion of deprotection by a technetium complex intermediate.

Accurate and timely diagnosis of prosthetic joint infection is essential to initiate early treatment and achieve a favorable outcome. In this study, we used a rabbit model to assess the feasibility of technetium-99m-labeled annexin V for detecting prosthetic joint infection. Right knee arthroplasty was performed on 24 New Zealand rabbits. After surgery, methicillin-susceptible Staphylococcus au...

Technetium-99m aprotinin was prepared from an optimised radiolabelling kit formulation containing aprotinin, alkaline buffer and stannous chloride (reducing agent) and radiolabelled using (99m) Tc-pertechnetate. The labelling was achieved within 25 min, with radiochemical purities of >98%.