OBJECTIVE Hepatocyte nuclear factor-4alpha (HNF4A) is a transcription factor that influences plasma triglyceride metabolism via an as of yet unknown mechanism. In this study, we searched for the critical protein that mediates this effect using different human model systems. METHODS AND RESULTS Up- and downregulation of HNF4A in human hepatoma Huh7 and HepG2 cells was associated with marked ch...

Technology Readiness Levels (TRLs) are a widely used metric of technology maturity and risk for marine renewable energy (MRE) devices. To-date, a large number of device concepts have been proposed which have reached the early validation stages of development (TRLs 1–3). Only a handful of mature designs have attained pre-commercial development status following prototype sea trials (TRLs 7–8). In...

Postprandial lipoprotein metabolism is impaired in hypertriglyceridemia. It is unknown how and to what extent atorvastatin affects postprandial lipoprotein metabolism in hypertriglyceridemic patients. We evaluated the effect of 4 weeks of atorvastatin therapy (10 mg/day) on postprandial lipoprotein metabolism in 10 hypertriglyceridemic patients (age, 40 +/- 3 years; body mass index, 27 +/- 1 kg...

The ability of human postprandial triacylglycerol-rich lipoproteins (TRLs), isolated after meals enriched in saturated fatty acids (SFAs), n-6 PUFAs, and MUFAs, to inhibit the uptake of 125I-labeled LDL by the LDL receptor was investigated in HepG2 cells. Addition of TRLs resulted in a dose-dependent inhibition of heparin-releasable binding, cell-associated radioactivity, and degradation produc...

The concurrence of visceral obesity, insulin resistance and dyslipidaemia comprises the concept of the metabolic syndrome. The metabolic syndrome is an escalating problem in developed and developing societies that tracks with the obesity epidemic. Dyslipidaemia in the metabolic syndrome is potently atherogenic and, hence, is a major risk factor for CVD (cardiovascular disease) in these subjects...

The epidemic of obesity in the developed and developing world has resulted in a considerable increase in the number of patients with high plasma triglyceride concentrations. There has been considerable debate about the role of triglyceride-rich lipoproteins (TRLs) in atherosclerosis. These lipoproteins include chylomicrons, VLDL, IDL, and various remnant particles. Although elevated triglycerid...

BACKGROUND Alimentary lipemia has been associated with coronary heart disease and common carotid artery intima-media thickness (IMT). This study was designed to investigate the relations of subclasses of postprandial triglyceride-rich lipoproteins (TRLs) with IMT. METHODS AND RESULTS Ninety-six healthy 50-year-old men with an apolipoprotein (apo) E3/E3 genotype underwent an oral fat tolerance...

This paper proposes the framework of TRL (Technology Readiness Level) transition predictions for early technology development in defense. Though predicting future TRLs is an important planning tool, it has been studied less actively than other critical issues on TRL, and previous studies mostly have resorted to domain experts. The proposed data-driven utilises both explanatory predictive modell...

Computing devices and applications are now used beyond the desktop, in diverse environments, and this trend toward ubiquitous computing is accelerating. One challenge that remains in this emerging research field is the ability to enhance the behavior of any application by informing it of the context of its use. By context, we refer to any information that characterizes a situation related to th...