Strong opioids are recommended for treating severe cancer pain in the advanced stages of the disease. Few data are available concerning the efficacy of buprenorphine in cancer pain. We compared transdermal buprenorphine 70 microg/h (BUP TDS) to placebo in an enriched design study. Opioid-tolerant patients with cancer pain requiring strong opioids in the dose range of 90-150 mg/d oral morphine e...

We show that nucleic acid structures may be conveniently and inexpensively characterized by their UV thermal difference spectra. A thermal difference spectrum (TDS) is obtained for a nucleic acid by simply recording the ultraviolet absorbance spectra of the unfolded and folded states at temperatures above and below its melting temperature (T(m)). The difference between these two spectra is the ...

Results The mean AUC(0,12 h) was higher following application of TDS ® -testosterone (61.8 ng ml − 1 h), compared with Androgel ® (57.7 ng ml − 1 h) and TDS ® -placebo (50.7 ng ml − 1 h. The mean C max (0,12 h) was similar for TDS ® -testosterone (6.6 ng ml −1 ) and Androgel ® (6.5 ng ml − 1 ) and these values were higher than those for TDS ® -placebo (5.7 ng ml − 1 ). Analysis of variance show...

The Tongue Drive System (TDS) is a minimally invasive, wireless, and wearable assistive technology (AT) that enables people with severe disabilities to control their environments using tongue motion. TDS translates specific tongue gestures into commands by sensing the magnetic field created by a small magnetic tracer applied to the user's tongue. We have previously quantitatively evaluated the ...

The 3.0-3.1A X-ray structures of the cytochrome b(6)f complex from Mastigocladus laminosus and Chlamydomonas reinhardtii obtained in the presence of the p-side quinone-analogue inhibitor tridecyl-stigmatellin (TDS) are very similar. A difference occurs in the p-side binding position of TDS. In C.reinhardtii, TDS binds in the ring-in mode, as previously found for stigmatellin in X-ray structures...

Recombinant proteins are widely used as biopharmaceuticals, but their production by mammalian cell culture is expensive. Hence, improvement of bioprocess productivity is greatly needed. A temperature downshift (TDS) from 37°C to 28-34°C is an effective strategy to expand the productive life period of cells and increase their productivity (qp). Here, TDS in Chinese hamster ovary (CHO) cell cultu...

In this article, we have developed models for threading dislocation ~TD! reduction due to the introduction of an intentionally strained layer. Three different types of dislocations have been considered in this model: misfit dislocations ~MDs!, mobile TDs, and TDs whose glide motion has been blocked by a MD crossing the glide path of the TD ~immobile TDs!. The models are based on MD formation by...

A parameter called TDS (Total Dermatoscopic Score), calculated by the wellknown ABCD formula, is frequently used in melanoma diagnosis. In our previous research we found a new formula, similar to the original ABCD formula, that yielded fewer diagnostic errors. This new ABCD formula was developed using data mining techniques, in particular, the rule induction algorithm LEM2, a part of the data m...

Temperature Discovery Search (TDS) is a forward search method for computing or approximating the temperature of a combinatorial game. Temperature and mean are important concepts in combinatorial game theory, which can be used to develop efficient algorithms for playing well in a sum of subgames. A new algorithm TDS+ with five enhancements of TDS is developed, which greatly speeds up both exact ...

Coxsackievirus B3 (CVB3) generates 5'-terminally deleted genomes (TDs) during replication in murine hearts. We show here that CVB3 populations with TDs can also be generated within two to three passages of CVB3 in primary, but not immortalized, cell cultures. Deletions of less than 49 nucleotides increase in size during passage, while 5' TDs of 49 nucleotides appear to be the maximum deletion s...