OBJECTIVES This study evaluated the immune response and safety profile of 13-valent pneumococcal conjugate vaccine (PCV13) in preterm infants compared with term infants. METHODS This Phase IV, open-label, 2-arm, multicenter, parallel-group study enrolled 200 healthy infants (preterm, n = 100; term, n = 100) aged 42 to 98 days. All subjects received PCV13 at ages 2, 3, 4 (infant series), and 1...

Citation: Fletcher JR, Crane DD, Wehrly TD, Martens CA, Bosio CM and Jones BD (2018) The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live Vaccine Strain. Front. Microbiol. 9:607. doi: 10.3389/fmicb.2018.00607 The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live...

This phase II clinical trial was conducted to compare the immunogenicity and safety of a newly developed tetanus-reduced diphtheria (Td) vaccine (GC1107-T5.0 and GC1107-T7.5) and control vaccine. This study was also performed to select the proper dose of tetanus toxoid in the new Td vaccines. Healthy adolescents aged between 11 and 12 yr participated in this study. A total of 130 subjects (44 G...

BACKGROUND The Hepatitis B (HB) vaccine response in hemodialysis patients is less than healthy individuals. Different strategies have been taken into account to improve the response rate. This study aimed to evaluate the effect of tetanus and diphtheria (Td) vaccine as an adjuvant therapy to HB vaccination. METHODS Sixty three end-stage renal disease patients were recruited on dialysis that w...

BACKGROUND Published data on the safety of tetanus-diphtheria-acellular pertussis vaccine (Tdap) in persons aged ≥65 years are limited. This study aims to examine a large cohort of Tdap users ≥65 years for evidence of increased risk of adverse events following vaccination. METHODS A matched cohort study design and a self-controlled case series (SCCS) design were used. The study population was...

Acute and severe Guillain Barre Syndrome (GBS) cases reported following influenza vaccine to the Vaccine Adverse Events Reporting System (VAERS) database from 1991 through 1999 were examined. Endotoxin concentrations were measured using the Limulus amebocyte lysate assay in influenza vaccines. There were a total of 382 cases of GBS reported to the VAERS database following influenza vaccination ...

Two-dimensional (TD) adaptive filtering is a technique that can be applied to many image, and signal processing applications. This paper extends the one-dimensional adaptive filter algorithms to TD structures and the novel TD adaptive filters are established. Based on this extension, the TD variable step-size normalized least mean squares (TD-VSS-NLMS), the TD-VSS affine projection algorithms (...

Peste des petits ruminants (PPR) is an acute and highly contagious fatal disease of small ruminants mainly affecting sheep and goats, and camels. PPR is endemic disease in many developing and tropical countries including Pakistan, and vaccine is currently the only means of disease control. However, lack of established infrastructures and high temperature, maintaining cold chain for effective de...

Vaccine-preventable diseases contribute significantly to the morbidity and mortality of U.S. adults. The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention updates its recommended adult immunization schedule annually. The most recent updates include the permissive but not routine use of the quadrivalent human papillomavirus vaccine to prevent genital ...

The IAP Committee on Immunization (COI) recommends offering Tdap vaccine instead of Td/ TT vaccine in all children / adolescents who can afford to use the vaccine(1). Tdap is a costly vaccine, which many parents may not be able to afford. There is a need for a less expensive vaccine, though slightly more reactogenic because of whole cell pertussis antigen in reduced quantity, with full dose of ...