نتایج جستجو برای: tcb
تعداد نتایج: 465 فیلتر نتایج به سال:
PURPOSE CEA TCB is a novel IgG-based T-cell bispecific (TCB) antibody for the treatment of CEA-expressing solid tumors currently in phase I clinical trials (NCT02324257). Its format incorporates bivalent binding to CEA, a head-to-tail fusion of CEA- and CD3e-binding Fab domains and an engineered Fc region with completely abolished binding to FcγRs and C1q. The study provides novel mechanistic i...
2,5,2',5'-Tetrachlorobiphenyl (TCB) induced type I binding spectra with cytochrome P450 (P450) 2A6 and 2A13, with Ks values of 9.4 and 0.51 µM, respectively. However, CYP2A6 oxidized 2,5,2',5'-TCB to form 4-hydroxylated products at a much higher rate (∼1.0 minute-1) than CYP2A13 (∼0.02 minute-1) based on analysis by liquid chromatography-tandem mass spectrometry. Formation of 4-hydroxy-2,5,2',5...
BACKGROUND Incidence of jaundice is high in newborn infants. Since well appearing newborns are rapidly and routinely discharged from hospital, performing an inexpensive noninvasive pre-discharge screening test for evaluation of jaundice seems to be necessary. OBJECTIVES This study was conducted to compare the accuracy of cutaneous v/s serum bilirubin measurements in this regard. PATIENTS AN...
BACKGROUND/AIMS Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and Trucut biopsy (TCB) are sensitive techniques for diagnosing mediastinal lesions, but it is unclear how either one or both should be used to obtain a pathologic diagnosis. The objective of our study was to evaluate whether EUS-TCB impacts the diagnosis of mediastinal lesions after the initial on-site review of EUS-...
CONTEXT Endoscopic ultrasound-guided trucut biopsy (EUS TCB) has a lower yield than fine needle aspiration (FNA) in pancreatic masses but the additional use of TCB to FNA may improve the diagnostic accuracy over FNA alone. OBJECTIVE To compare the yield of EUS FNA alone or combined with EUS TCB for diagnosis of pancreatic masses. DESIGN Single center retrospective case control study conduct...
Objective: To evaluate the relation between transcutaneous bilirubin (TcB) by BiliChek and total serum bilirubin (TSB) in the Chinese neonates compared with another transcutaneous Bilirubinometer (VanHou). Methods: TcB measurements were performed on the forehead by Bilichek and VanHou. Total serum bilirubin (TSB) was determined within 5 minutes after TcB measurement. The correlation and agreeme...
This study aimed to evaluate the long-term efficacy and safety of a generic tacrolimus (Tacrobell [TCB]) compared to the original tacrolimus (Prograf [PGF]) in kidney transplant recipients. In this retrospective observational study, we analyzed the data from 444 patients who took TCB as a first-line immunosuppressive drug and 245 patients who took PGF. The 5-year graft survival rate was 92% for...
BACKGROUND Transcutaneous bilirubin (TcB) meters are widely used for screening newborns for jaundice, with a total serum bilirubin (TSB) measurement indicated when the TcB value is classified as "positive" by using a decision rule. The goal of our study was to assess the clinical utility of 3 recommended TcB screening decision rules. METHODS Paired TcB/TSB measurements were collected at 34 ne...
BACKGROUND/AIMS To evaluate the yields and utility of 19-gauge (G) Trucut biopsy (TCB) versus 22 G fine needle aspiration (FNA) for diagnosing gastric subepithelial tumors (SETs). METHODS We retrieved data for 152 patients with a gastric SET larger than 2 cm who had undergone endoscopic ultrasonography (EUS)-guided 19 G TCB (n=90) or 22 G FNA (n=62). Relevant clinical, tumor-specific, and EUS...
In their study of the routine use of transcutaneous bilirubin (TcB) measurements in 27 well infant nurseries, Taylor et al found that 2.2% of TcB measurements underestimated the clinical laboratory measurement of total serum bilirubin (TSB) by $3.0 mg/dL, and the tendency for TcB to underestimate TSB increased with advancing newborn age (presumably up to the length of stay of a normal newborn)....
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