Neuroblastoma (NB) is the most common solid tumor in pediatric cases. NB accounts for about 8% of malignancies patients younger than 15 years, and since 50% newly diagnosed cases metastasize to regional lymph nodes, bone marrow, bone, liver, skin, disease usually its late stages. Overexpression N-MYC, which characterized by poor prognosis NB, changes progression course treatment. Targeting thes...

To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targete...

objective(s): pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. researchers have intended to reformulate drugs so that they may be more safely used in human body. the more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. the aim of t...

Brain-targeted drug delivery is a field of research that seeks to develop new methods for delivering drugs the brain. This done by overcoming blood-brain barrier (BBB), network cells tightly regulate flow substances between blood and Most time lipophilic are easily cross brain but few them less soluble in lipid therefore they don’t barrier. After review we concluded can improve solubility using...