Enhanced endoplasmic reticulum (ER) stress leads to cell death in various pathophysiological situations. During a search for compounds that regulate ER stress, we identified methoxyflavones, a group of flavonoids, as strong protective agents against ER stress. Analysis in mouse insulinoma MIN6 cells revealed that methoxyflavones mildly activated the eukaryotic initiation factor 2alpha and nucle...

A new flavone, named crotoncaudatin (1), was isolated from the stems of Croton caudatus Geisel. var. tomentosus Hook., together with nine known analogues: 3,5,6,7,8,3',4'-heptamethoxyflavone (2), tangeretin (3), nobiletin (4), 5,6,7,4'-tetramethoxy-flavone (5), sinensetin (6), kaempferol (7), tiliroside (8), kaempferol-3-O-rutinoside (9) and rutin (10). The structures of the above compounds wer...

Citrus peels were successively extracted with hexane, chloroform and acetone using a soxhlet extractor. The hexane and chloroform extracts were fractionated into alcohol-soluble and alcohol-insoluble fractions. These fractions were tested against different gram positive and gram negative bacteria. The EtOH-soluble fraction was found to be most effective. Fractionation of EtOH-soluble fraction o...

Hợp chất flavone, tangeretin (1), và ba hợp steroid: ergosterol peroxide (2), sitoindoside I (3) stigmasterol (4) đã được phân lập từ thân rễ của cây thiên niên kiện lá lớn (Homalomena pendula). Cấu trúc hóa học chúng xác định dựa trên tích dữ liệu phổ cộng hưởng hạt nhân (1D 2D NMR) so sánh với các tài công bố. Các (1-3) lần đầu tiên chi Homalomena. Cao chiết n-hexane ethyl acetate này có hoạt...

Purpose: This study was designed to find an answer the question, "Is it beneficial use pomegranate (POM) and tangeretin (TAN) separately or in combination, for prevention of acute gastric ulcer?". 
 Materials Methods: The gastroprotective effect determined by measuring levels selected inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β IL-10], lipid peroxid...

Targeted therapy has been a very promising strategy of drug development research. Many molecular mechanims of diseases have been known to be regulated by abundance of proteins, such as receptors and hormones. Chemoprevention for treatment and prevention of diseases are continuously developed. Pre-clinical and clinical studies in chemoprevention field yielded many valuable data in preventing the...