BACKGROUND Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. OBJECTIVE Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. MATERIALS AND ME...

objective: pimpinella anisum (p. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. in this study the antidepressant-like effect of aqueous and ethanolic extracts of p. anisum fruit in mice was investigated. materials and methods: forced swimming test (fst) and tail suspension test (tst) were used to determi...

Recent findings support the hypothesis that CB receptor blockade might be associated with antidepressant and anti-stress effects. In the current study, the anti-depressant-like effects of rimonabant were studied in validated models of depression. Rimonabant (4-8mg/kg, i.p.) significantly decreased the duration of immobility in a dose dependent manner in mice forced swim test (FST) and in tail s...

BACKGROUND The present study was undertaken to evaluate the anti-depressive activity of turmerone after one-week administration by using a mouse forced swimming test (FST) and tail suspension test (TST). METHODS Animals were divided into four groups (n = 10 /group): control (0.9% saline), the three doses of turmerone (1.25, 2.5, 5.0 mg/kg) for one-week treatment. To assess the effect of turme...

CONTEXT In traditional system of medicine brahmi has been used to enhance memory. Recently it has been reported to have action in psychiatric disorders. With these backgrounds the work has been undertaken to study antidepressant activity of brahmi in albino mice. AIM To evaluate antidepressant activity of brahmi in experimental models. MATERIALS AND METHODS The antidepressant activity was s...

OBJECTIVES This study planned to assess antidepressant like activity of aqueous extract from leaves of Citrus maxima Merr. (Rutaceae). MATERIALS AND METHODS Boiling was used for aqueous extraction. Acute toxicity study was performed in mice. Antidepressant activity was studied using locomotor activity test, modified forced swimming test (FST) and tail suspension test (TST). Three doses 100, 2...

The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitoster...

The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that are expected to affect depression related behaviors. Mice are suspended by their tails with tape, in such a position that it cannot escape or hold on to nearby surfaces. During this test, typically six minutes in duration, the resulting escape ...

BACKGROUND The prefrontal cortex plays a critical role in regulating emotional behaviors, and dysfunction of prefrontal cortex-dependent networks has been broadly implicated in mediating stress-induced behavioral disorders including major depressive disorder. METHODS Here we acquired multicircuit in vivo activity from eight cortical and limbic brain regions as mice were subjected to the tail ...