نتایج جستجو برای: tacrine
تعداد نتایج: 1379 فیلتر نتایج به سال:
The effect of ethanolic extract of Coriandrum sativum L. seeds (100, 200 mg/kg) was studied on tacrine induced orofacial dyskinesia. Tacrine (2.5 mg/kg, i.p.) treated animals were observed for vacuous chewing movements (VCM), tongue protrusions (TP) and orofacial bursts (OB) for 1 h followed by observations for locomotor changes and cognitive dysfunction. Sub-chronic administration of Coriandru...
The original version of this article was published with an incorrect label for Fig. 4c. The labels 'no tacrine' and '3 mM tacrine' were associated with the incorrect fluorescence micrographs. The correct version of Fig. 4 appears below.
The binding and function of muscarinic acetylcholine receptors can be modulated allosterically. Some allosteric muscarinic ligands are "atypical", having steep concentration-effect curves and not interacting competitively with "typical" allosteric modulators. For atypical agents, a second allosteric site has been proposed. Different approaches have been used to gain further insight into the int...
The complex and multifactorial nature of neuropsychiatric diseases demands multi-target drugs that can intervene with various sub-pathologies underlying disease progression. Targeting the impairments in cholinergic glutamatergic neurotransmissions small molecules has been suggested as one potential disease-modifying approaches for Alzheimer’s (AD). Tacrine, a potent inhibitor acetylcholinestera...
The excessive activation of the N-methyl-D-aspartate receptor (NMDAR)/nitric oxide (NO) pathway has been proposed to be involved in the neuropathology of various neurodegenerative disorders. In this study, NO was found to mediate glutamate-induced excitotoxicity in primary cultured neurons. Compared with the NO synthase (NOS) inhibitor, N(G)-monomethyl-L-arginine (L-NMMA), and the NMDAR antagon...
The purpose of this paper is to examine whether oxiracetam and aniracetam are more effective than donepezil and tacrine, two drugs currently used to treat Alzheimer’s disease. Past research suggests that oxiracetam and aniracetam are more therapeutically efficacious than donepezil and tacrine in the treatment of Alzheimer’s disease symptoms (i.e., cognitive deterioration, tolerability, and qual...
Morphine and morphine with tacrine (tetrahydroaminacrine) have been compared when given intramuscularly as premedication, with regard to the pre-operative state of the patient, course of anaesthesia, sequelae, and effects on reactions to suxamethonium. Tacrine appeared to increase the pre-operative toxic effects of morphine, namely dizziness and nausea. During anaesthesia, hypotension was less ...
AIM To study the effects of huperzine-A on neuromuscular junction transmission in mouse. METHODS The isolated mouse phrenic nervehemidiaphragm preparations were used with the conventional intracellular recording technique. The spontaneous electrical activities of cholinergic nerve terminals (miniature end-plate potentials, MEPP) were recorded. RESULTS Huperzine-A, tacrine, and E2020 at the ...
Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors.
A series of new Tacrine analogs modified with nitroxides or pre-nitroxides on 9-amino group via methylene or piperazine spacers were synthesized; the nitroxide or its precursors were incorporated into the Tacrine scaffold. The new compounds were tested for their hydroxyl radical and peroxyl radical scavenging ability, acetylcholinesterase inhibitor activity and protection against Aβ-induced cyt...
In vivo effects of reversible inhibitors of cholinesterase activity were determined radiometrically in undiluted samples of erythrocytes and plasma. [14C]acetylcholine at substrate saturation, 25 degrees C and pH 7.4 permitted rapid and precise determination of butyrylcholinesterase (EC 3.1.1.8) and acetylcholinesterase (EC 3.1.1.7) activities. Reference values for acetylcholinesterase and buty...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید