This review provides an insight into mechanical properties that are critical to understanding powder processing for tableting. Various parameters that reflect these basic fundamental properties of powder and their evaluation by different techniques are described. Some recent examples in which these techniques are used in drug substance selection, formulation optimization or scale-up are also pr...

Citrus kawachiensis peel (PCK), a new functional food material, may prolong the healthy life expectancy of aging populations. Tableting PCK could facilitate its worldwide distribution and consumption. A dosage form that is easy to swallow should be prepared for ease use by elderly. We investigated fabrication orally disintegrating (OD) tablets with required commercial strength disintegration ti...

www.pharmtech.com initial costs of operation, and confusion about validation. Two developments, however, may now change the industry’s collective mindset: an increase in innovative, customized designs that make it possible to use barrier isolators in applications such as tableting and containment of highly potent compounds and, most important, the release of FDA’s long-awaited revised CGMP Draf...

The present work was aimed at formulation development, evaluation and comparative study of the effects of superdisintegrants in Cefixime 50 mg oral disintegrating tablets. The superdisintegrants used for the present study were sodium starch glycolate and crosscarmellose sodium. The formulated tablets were evaluated for various tableting properties, like hardness, thickness, friability, weight v...