UNLABELLED The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs demonstrate potent immunosuppressive properties. The present study investigated ...

The increasing presence of drug-resistant bacterial infections among hospitalAbstract ised patients has resulted in greater numbers of patients receiving inappropriate antimicrobial treatment. This has led to the development of a novel paradigm guiding the administration of empirical antimicrobial therapy for patients with serious infections in the hospital setting. Antibacterial de-escalation ...

Periodontal diseases are considered infection of the periodontium, because there is bacterial etiology, an immune response, and tissue destruction. Putative pathogens associated with periodontal diseases are susceptible to a variety of antiseptics and antibiotics. Methods employed to convey antimicrobial agents into periodontal pockets have included rinsing, irrigation, systemic administration,...

PURPOSE In vitro antibacterial activity of topical and systemic antihistaminic preparations containing different active substrates against the standard strains of two bacteria was evaluated. METHODS Four topical and 3 systemic preparations containing pheniramine maleate, chlorophenoxamine hydrochloride, and diphenhydramine hydrochloride were studied. The antibacterial activities of these prep...

INTRODUCTION The rise in antimicrobial resistance is a major global concern and requires new treatment strategies. The use of helper compounds, such as thioridazine (TDZ), an antipsychotic drug, in combination with traditional antibiotics must be investigated. OBJECTIVES The aim of this study was to investigate the efficacy of TDZ as a helper compound for dicloxacillin (DCX) against methicill...

BACKGROUND Antibacterial drug use is a major risk factor for bacterial resistance, but little is known about antibacterial use in US hospitals. The objectives of this study were to characterize trends in antibacterial use in a sample of US hospitals and to identify predictors of use. METHODS We measured systemic antibacterial use from validated claims data at 22 university teaching hospitals ...

The cyanoacrylate polymer particles, which do not contain antibiotics or antibacterial agents, bond with the cell wall of drug-resistant bacteria, and then induced an auto-destructive behavior that causes the bacteria to destroy itself. Because of this, the drug-resistant bacteria are unable to arise. One noteworthy point of this nano-polymer is that it excels in safety given its induction of b...

Neuro-inflammation, biochemical and cellular responses of the nervous system to injury, infection or neurodegenerative diseases, is a major risk factor for Alzheimer's, Parkinson's and Multiple Sclerosis. Periodontitis is a serious bacterial gum infection that damages the soft tissue and teeth supporting bones, causing teeth loss. It also renders systemic inflammation by secretion of pro-inflam...

As a major proportion of antibacterials used in hospital practice are for surgical prophylaxis, an audit of practice in relation to antibacterial prophylaxis in general surgery was undertaken over a four week period in a teaching hospital to assess the extent to which principles governing surgical antibacterial prophylaxis were practised and to provide a feedback to the clinicians. The extent o...