objective(s):  apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (sle), in present study we studied the apoptosis in t lymphocytes from iranian sle patientsat protein and gene expression levels for some molecules which are involved in apopt...

conclusions while bdg assay seems to be a sensitive and specific adjunctive tool to diagnose and monitor the experimental systemic candidiasis, it seems that measuring the positive cutoff value in different laboratory conditions is necessary for favorable establishment of these tests. results all the infected rats were positive with bdg tests. an increasing level of bdg was observed during earl...

systemic amyloidosis is a very rare complication of inflammatory bowel disease (ibd). the reported cases of secondary amyloidosis in children with ibd are much fewer than those reported in adults. herein, a teenage boy with crohn’s disease is presented who developed nephrotic syndrome due to renal involvement secondary to amyloidosis, whereas the patient was under treatment with corticosteroid ...

background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...

deep-seated fungal infection present with non specific symptoms and involove a large number of different organisms. dna-based technology offers for eariler detection of fungal pathogens and then earlier initiation of antifungal therapy. in this study universal primers common to almost all fungi were used to amplification of internal transcribe spacer 1 and 2 region. subsequent restriction enzym...

conclusions thyroid dysfunction was not higher in sle patients compared to healthy individuals. however, anti-tg antibodies were higher in sle patients. it has not yet been established that thyroid function tests should be performed routinely in sle patients. results the mean age of sle patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (p = 0.821). patients had signif...

background: cardiac involvement in systemic sclerosis (ssc) is more prevalent than previously thought. in this study, the frequency and severity of cardiovascular involvement were assessed in ssc patients referred to firouzgar hospital. methods: fifty-eight patients with ssc, selected from the data bank of ssc patients, were reviewed for the frequency and severity of 8 organ involvements in thi...

background: the aim of the present study was to determine the prevalence and prognosis of cerebrovascular accident(cva) and its subtypes among iranian patients with systemic lupus erythematosus (sle). methods: in a cross-sectional study, medical records of 575 sle patients were reviewed. the patients developing cva in their course of disease were extracted. in these patients, data about demogra...

purpose: to evaluate the results of combined chemotherapy and periocular carboplatin injection to control advanced intraocular retinoblastoma (rb). methods: in this prospective interventional case-series, we included 8 eyes of 8 patients with advanced intraocular rb (group c or d in international intraocular retinoblastoma classification, iirc). in these patients, periocular carboplatin was inj...