In this paper, the synthesis and free-radical scavenging capacity of novel calix[4]arene-based cluster of paracetamol was reported. The phenolic structures of acetaminophen and calix[4]arene prompted us for designing a synthetic route for calix[4]arene-based cyclic tetramer of paracetamol. The present chalice-shaped cluster is the first example of calixarene/acetaminophen hybrid and paracetamol...

In this paper, the synthesis and free-radical scavenging capacity of novel calix[4]arene-based cluster of paracetamol was reported. The phenolic structures of acetaminophen and calix[4]arene prompted us for designing a synthetic route for calix[4]arene-based cyclic tetramer of paracetamol. The present chalice-shaped cluster is the first example of calixarene/acetaminophen hybrid and paracetamol...

Objective(s): In a new approach, following the development in metal oxide chemistry, the ibuprofen as low water soluble nonsteroidal anti-inflammatory drug diffused into synthetic sol-gel derived nano porous g-alumina by an impregnation method in order to increase the solubility and control the drug release in physiological environment. Methods: Sol-gel m...

objective(s): in this research, zeolite x and zeolite y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. materials and methods: a soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. gravimetric methods and ir spectra of prepared formulations were used to assess drug loading efficiencies into...

Synthetic biology (SB) is an emerging discipline, which is slowly reorienting the field of drug discovery. For thousands of years, living organisms such as plants were the major source of human medicines. The difficulty in resynthesizing natural products, however, often turned pharmaceutical industries away from this rich source for human medicine. More recently, progress on transformation thro...