objective(s): investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. this study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. materials and methods: male, 12-week-old wistar rats i...

Metabolic syndrome includes the following symptoms: obesity, hyperlipidemia, hypertension, insulin resistance, and cardiovascular disease. The purpose of this review is to elucidate role adipokines in regulation L-arginine-NO-synthas-NO signaling pathway pathogenesis metabolic syndrome. main questions raised are: how adipokine secretion changes, level their receptors regulated, which pathways a...

Die Sesterviolen-Synthase aus Streptomyces violens wurde identifiziert und repräsentiert die zweite bekannte Sesterterpen-Synthase Bakterien. Es wurden Isotopenmarkierungsexperimente in Verbindung mit DFT-Rechnungen durchgeführt, detaillierte Einblicke ihren komplexen Cyclisierungsmechanismus lieferten. Enzym-Engineering durch ortsgerichtete Mutagenese ermöglichte den Zugang zu einer hochergieb...

background: migraine is a chronic  neurological  disorder, characterized  by recurrent  moderate to severe headaches. worldwide migraine a=ects nearly 15%. studies suggest that genes involved in the production of nitric oxide (no) may act as genetic  factors for migraine. no synthase  3 (nos3) by expressing  enzyme nos regulates  endothelial  derived no. one  class of  medications   used  as  f...

introduction: ischemia/reperfusion (ir) injury involves a complex interrelated sequence of events. high levels of nitric oxide (no) are generated with inducible form of nitric oxide synthase (inos) leading to the renal ir injury and glutathione (gsh) depletion. the present study was designed to investigate the effect of l-nil (n6- (1-iminoethyl)-l- lysine.hydrochloride), a selective inhibitor o...

Vasoplegic shock refractory to vasopressors is associated with significant morbidity and mortality. Catecholamine driven therapies are first-line in the management of vasoplegic shock. Research regarding use non-catecholamine agents setting lacking. Methylene blue has multiple off-labelled indications for use, but recently been suggested have a role treating mediated by dysregulation nitric oxi...

Peppermint has considerable commercial value and widely cultivated for essential oil production, especially menthol. The aim of this study was to determine the quantitative expression of pulegone reductase (pr), menthofuran synthase (mfs) and limonene synthase (ls) genes in menthol biosynthesis pathway in Mentha x piperita , using semiquantitative RT-PCR analysis and evaluating menthol producti...

Background and Purpose: Soleshine is a polyherbal preparation established in the market for the treatment of cracks and tinea pedis, which is applied externally. This preparation is composed of the extracts of indigenous plants, namely Azadirachta indica, Lawsonia alba, and Shorea robusta, mixed with castor oil and sesame oil. In the present study, an attempt was made to identify the constituen...

indirect evidence suggests that estrogen is involved in the etiology of breast cancer. estrogen is also thought to modulate nitric oxide (no) in human breast tumor tissue via regulation of inducible nitric oxide synthase (inos). objectives of this study were to determine whether estradiol (e2) affects inos expression level in breast cancer cells and to study the effect of various concentrations...