For the first time, α-formyldiazoacetates have been successfully applied for the asymmetric cyclopropanation of alkenes via Co(ii)-based metalloradical catalysis. The cobalt(ii) complex of the D2-symmetric chiral amidoporphyrin [Co(3,5-Di t Bu-ChenPhyrin)] is an effective metalloradical catalyst that can activate α-formyldiazoacetates to cyclopropanate both aromatic and aliphatic olefins with v...

The development of the first highly active enantioselective catalyst for the aza-Claisen rearrangement of Z-configured allylic trifluoroacetimidates generating valuable almost enantiopure protected allylic amines is described. Usually Z-configured allylic imidates react significantly slower than their E-configured counterparts, but in the present study the opposite effect was observed. Z-Config...

After five decades of largely serendipitous (albeit formidable) progress, catalyst design in Ziegler-Natta olefin polymerization, i.e., the rational implementation of new active species to target predetermined polyolefin architectures, has ultimately become a realistic ambition, thanks to a much deeper fundamental understanding and major advances in the tools of computational chemistry. In this...

Crambescidins and batzelladines, novel marine guanidine alkaloids, have unique pentacyclic and tricyclic guanidine core structures, respectively. They display a considerable array of biological activity and not surprisingly have attracted considerable synthetic interest. The first total synthesis of crambescidin 359 (7) and stereoselective total synthesis of batzelladine D (11) were accomplishe...

in this paper we introduce two symmetric variants of amenability, symmetric module amenability and symmetric connes amenability. we determine symmetric module amenability and symmetric connes amenability of some concrete banach algebras. indeed, it is shown that $ell^1(s)$ is  a symmetric $ell^1(e)$-module amenable if and only if $s$ is amenable, where $s$ is an inverse semigroup with subsemigr...

In this issue of Chem Catalysis, Wang et al. report the synthesis 1,1-cyclopropanediesters promoted by a D2-symmetric chiral amidoporphyrin catalyst. The carbene transfer from unsymmetrical diazomalonates to large scope challenging alkenes occurred with high stereocontrol thanks efficiency Co(II)-based metalloradical catalytic system.

Aqueous biphasic catalysis is a convenient approach to convert organic, partially soluble molecules in water. However, converting more hydrophobic substrates is much more challenging as their solubility in water is extremely low. During the past ten years, substantial progress has been made towards improving the contact between hydrophobic substrates and a hydrophilic transition-metal catalyst....

This paper argues that Information Technology (IT) needs to be demystified, through critical consciousness, for educators to focus on IT as a means to enhance learning. It goes on to define the technical, sociohistorical and political-ideological levels of IT and to identify four theoretical constructs: tutorial, machine-as-human, tool kit and catalyst. Pervading these constructs is the underst...

In order to design improved chiral ruthenium catalysts for asymmetric olefin metathesis, enantiomeric catalysts incorporating C1-symmetric N-Heterocyclic carbenes (NHC) ligands with syn-related substituents on the backbone were synthesized starting from meso-1,2-diphenylethylenediamine. The absolute configuration of the enantiomers of the desymmetrized meso diamine was assigned by optical rotat...