it has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. in order to improve the bioavailability, the release behavior of such drugs should be improved. although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...

in this study, the effects of various hydrophilic (hpmc and carbopol 971) and plastic (ethylcellulose and eudragit rl100) polymers on the release profile of diltiazem hcl from matrix tablets were evaluated in-vitro. for this purpose, tablets containing 60 mg of diltiazem hcl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. tablets prep...

Affinity-based release systems use transient interactions to sustain and control the release of a therapeutic from a polymeric matrix. The most common affinity-based systems use heparin-based scaffolds to sustain the release of heparin-binding proteins, such as fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF). However, novel affinity-based systems based on, for ex...

We introduce a time-domain model for the synthesis of attack and release parts of musical sounds. This approach is an extension of a spectral synthesis model we developed: the Reduced Parameter Synthesis Model (RPSM). The attack and release model is independent from a preceding spectral analysis as it is based on the time domain sustain part of the sound. The model has been tested with linear a...