An immunocompetent woman presented with a hypersensitivity skin reaction following suppressive therapy with aciclovir for recurrent culture proved genital herpes simplex virus infection. She developed a similar reaction when treatment was changed to famciclovir. Without antiviral suppression her recurrences were frequent and distressing. Graded challenge was performed and she became tolerant to...

Objective: Trials of herpes simplex virus (HSV) suppressive therapy among HSV-2/HIV-1infected individuals have reported an impact on plasma HIV-1 viral loads (PVL). Our aim was to estimate the population-level impact of suppressive therapy on female-to-male HIV-1 sexual transmission. Design and methods: By comparing preand post-randomisation individual-level PVL data from the first two HSV supp...

Background: Suppressive therapy with levothyroxine for reducing the size of thyroid nodules has not been really accepted. The purpose of this study was to assess the effect of levothyroxine on the size of benign thyroid nodules. Methods: Forty patients with confirmed benign nodule were randomly divided into two groups. Group I received 50?g/day levothyroxin for six months but group II did not t...

Background: The ultimate goal of the treatment of infectious knee arthritis is to protect the articular cartilage fromadverse effects of infection. Treatment, however, is not always hundred percent successful and has a 12% failurerate. Persistent infection is more likely to happen in elderly patients and those with underlying joint diseases,particularly osteoarthritis. Eradica...

Gastroesophageal reflux disease (GERD) is an extremely common chronic disorder associated with impaired quality of life and huge economic burden. Recently, an International Consensus Group developed a global definition of GERD (The Montreal Definition): a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. The traditional endoscopy-based...

We have examined the susceptibility to acyclovir and frequency of acyclovir-resistant viruses in herpes simplex virus type (HSV) 2 clones isolated directly from genital lesions of 11 patients who had taken suppressive therapy (200 mg/day) for 1-9 years and 15 patients naive to acyclovir. Suppressive therapy significantly reduced the incidence of recurrence and the severity of the skin lesions. ...

Context The effect of thyrotropin (TSH) suppressive therapy on trabecular bone scores (TBSs) is unclear. Objective The aim of this study was to investigate the effect of TSH suppression on vertebral TBSs of postmenopausal women with differentiated thyroid carcinoma (DTC). Design, Setting, and Participants We conducted a retrospective cohort study including 273 postmenopausal women with DTC ...

Overwhelming evidence from observational epidemiological studies indicates that herpes simplex virus type 2 (HSV-2) infection enhances the risk of acquiring HIV infection. Studies of genital shedding of HIV have suggested that HSV-2 infection also increases the onward transmission of HIV-1 by HIV/HSV-2 co-infected patients. Several randomized controlled trials were initiated to assess the impac...

Around the world, candidemia is becoming more common. In past thirty years, a number of factors, including AIDS epidemic, an increase in patients receiving immune-suppressive therapy for transplantation, and use antibiotics hospital settings even community, have changed epidemiology invasive fungal infections general particular. Usage broad-spectrum antibiotics, cancer treatment, Candida specie...