Aim: The majority of cancer patients develop cancer cachexia (CC). CC is a debilitating and life-threatening, multifactorial condition that is characterized by altered metabolism and reduced food intake, contributing to weight loss (mainly lean body mass). Existing treatment approaches are limited in their ability to treat CC, while too little is currently done to prevent it. Surveys were carri...

Dose and schedule are important factors in the therapy of cancer. Animal model and clinical data show that there is a significant correlation between dose-intensity and survival; moreover, the shortening of interval between chemotherapy cycles prevents from tumor regrowth and maximize the effect of chemotherapy on cancer cells (Gregory SA, Trumper L, 2005). Most of anti-cancer drugs are non-sel...

abstract background: the emotional bond that a mother feels towards her infant is critical to their social, emotional, and cognitive development. this concept has a major influence on an infant’s future health, and growth, so the assessment of parental-fetal attachment and related factors is of great importance. this study aimed to examine the effect of psychological intervention on attachment ...

Vascular endothelial (VE)-protein tyrosine phosphatase (PTP) associates with VE-cadherin, thereby supporting its adhesive activity and endothelial junction integrity. VE-PTP also associates with Tie-2, dampening the tyrosine kinase activity of this receptor that can support stabilization of endothelial junctions. Here, we have analyzed how interference with VE-PTP affects the stability of endot...

Acute respiratory distress syndrome (ARDS) is a life-threatening condition for which there are currently no medical therapies other than supportive care involving the application of mechanical ventilation. However, mechanical ventilation itself can worsen ARDS by damaging the alveolocapillary barrier in the lungs. This allows plasma-derived fluid and proteins to leak into the airspaces of the l...

B ilirubin can cross the blood-brain barrier, especially when plasma concentrations are high and in neonates. Bilirubin is toxic and can lead to irreversible brain damage, signs of neurologic disease, and coma, which is called “kernicterus.” The most important cause of clinical icterus in equine neonates is neonatal isoerythrolysis (NI), an alloimmune disease characterized by immune-mediated he...

conclusions the influences of various facilities and barriers were different in the physical activity of elderly in kashan. the promotion of active life style should be a part of health care planning in elderly. background the supplements and decreasing the limitations are important for suitable physical activity. these factors are different in various environments. objectives the current study...