In this work, the surface of porous titanium samples obtained by space-holder technique was treated with a femtosecond laser to improve their osseointegration. Instrumented micro-indentation and scratch test were implemented evaluate tribo-mechanical behavior modified samples. A detailed study micro-hardness, stiffness, resistance elastic recovery performed. Also, in vitro analysis carried out ...

Cored beads (also known as pellicular, superficially porous, and fused-cored beads or particles) offer advantages over fully porous beads in reduced diffusional mass transfer resistances in particle macropores and separation times in liquid chromatography (LC). They are also used to regulate bead densities. The core of a bead has a relatively small volume and yet presents a large linear distanc...

Ultrafast reversed-phase high-performance liquid chromatographic (HPLC) separations are often needed for analyses related to combinatorial chemistry, studies in liquid chromatography-mass spectrometry, and other applications in which very rapid sample turnaround is paramount. Unfortunately, no consensus exists regarding the best column technology for optimally performing the desired rapid separ...

In this month’s “Column Watch,” Ron Majors discusses advances in multidimensional chromatography and comprehensive multidimensional chromatography. These techniques are well suited for the separation of complex samples. Although GC GC is fairly well developed, LC LC is in its infancy. But with fast LC columns, based on monoliths, superficially porous particles, and short sub-2m particle columns...

The article describes the development of new stationary phases for analysis proteins in reversed phase liquid chromatography (RPLC). goal was to have columns offering high recovery at low temperature, hydrophobicity and novel selectivity. For this purpose, three different ligands bound onto surface superficially porous silica-based particles were compared, including trimethyl-silane (C1), ethyl...

The compatibility of superficially porous (SP) resin for label-free intact protein analysis with online capillary LC/MS is demonstrated to give improved chromatographic resolution, sensitivity, and reproducibility. The robustness of the platform was measured against several samples of varying complexity and sample loading amount. The results indicate that capillary SP columns provide high loadi...