BACKGROUND Natural polymers serve as cheap, non-toxic, biocompatible excipients in drug delivery. OBJECTIVES Starch from wheat (Triticum aestivum) was investigated as a disintegrant in metronidazole tablet formulations in comparison with sodium starch glycolate (SSG), a standard, synthetic but relatively more expensive disintegrant. MATERIAL AND METHODS Native wheat starch (NAS) was modifie...

In the past few years, there are number of researchers carrying out their research on the excipients derived from polysaccharides and some of these researches show that natural excipients are comparable and can serve as an alternative to the synthetic excipients. Hence, the objectives of this research are to characterize the naturally sourced chickpea starch powder and to study the pharmaceutic...

Conventional solid dosage form suffers from problem like difficulty in swallowing with age, onset of action and physiological factor of patient like gastric emptying time. To overcome this mouth dissolving tablet is a newer approach to drug delivery. Zolpidem is preferentially used for the short term treatment of insomnia. The aim of present study is to formulate and evaluate mouth dissolving t...

The current work evaluate directly compressible esomeprazole magnesium trihydrate enteric coated tablets were prepared to deliver drug in upper GIT. Different tablets were prepared with super disintegrants like Ac-Di-Sol, Crospovidone, sodium starch glycolate and diluents like Pharmatose DCL11, Mannogem EZ. Tablets were enteric coated using Acryl-EZE. The tablets were evaluated for hardness, di...

The aim of present study was to prepare and evaluate mouth dissolving tablets of ibuprofen (IBU). Ternary solid dispersion (SD) of IBU was prepared using PEG 4000 as carrier and Tween 80 as surfactant. The SD formulations were prepared by solvent evaporation and melt solvent method by varying ratio of PEG 4000. Different weight ratio of carrier, drug and surfactant 5 : 5 : 1, 10 : 5 : 1, 25 : 5...

Oral administration of dosage form is the most recommended mode administration, because its self-medication, accurate dose drug, and ease administration. However, trouble swallowing in geriatric patients one major negative this route, which can mentally disrupt patients. The goal study was to use direct compression method make orodispersible tablets sulindac utilizing various doses super disint...

The aim of this study was to evaluate the influence of disintegration mechanism of various types of disintegrants on the absorption ratio (AR), wetting time (WT), and disintegration time (DT) of orodispersible tablets (ODTs). ODTs were prepared by direct compression using mannitol as filler and disintegrants selected from a range of swellable, osmotic, and porous disintegrants. Tablets formed w...