Written instructions and accompanying photographs dealing with self-administration of sumatriptan are available at most pharmacies and are enclosed in the self-dosing kit you will receive with your initial prescription. While preparation of the auto-injector is not particularly difficult, it is a good idea to familiarize yourself with its use during a quiet time when you are free of headache or...

OBJECTIVE To compare the efficacy of ketorolac nasal spray (NS) vs. placebo and sumatriptan NS for the acute treatment of migraine. METHODS This was a randomized, double-blind, placebo and active-comparator, crossover study. Adult migraineurs were randomized to ketorolac NS 31.5 mg, sumatriptan NS 20 mg, or placebo to treat three moderate to severe migraine attacks and switched treatments wit...

migraine is a common and incapacitating neurologic disorder manifesting with episodic moderate to a severe headache and other symptoms such as photophobia, phonophobia, nausea, and vomiting. triptans and ergot compounds have been used as treatment options for an acute migraine headache for many years. triptans are considered the first line of treatment in patients with moderate to a severe migr...

The paper by MB Vincent et 31. in this issue represents a further piece of investigation on the mechanism of action of sumatriptan. It focuses on the efficacy of the drug in aborting cluster headache ( CHj attacks, a clinical condition for which sumatriptan is highly effective and now represents the treatment of choice. The authors have chosen porcine ophthalmic artery ( POAj for evaluating the...

OBJECTIVE To evaluate the impact on costs and outcomes of early migraine treatment with sumatriptan while pain is mild versus sumatriptan treatment of moderate to severe pain. BACKGROUND Migraines result in substantial pain, impairment, and costs. Recent clinical studies have shown that early treatment with sumatriptan when migraine pain is mild is more effective than sumatriptan treatment wh...

background: sodium valproate (sv) has been approved for migraine prophylaxis and its intravenous form is used to treat acute migraine attacks. we compared the efficacy and safety of intravenous sv and subcutaneous sumatriptan in managing acute migraine attacks. methods: this double-blind randomized clinical trial divided 90 patients into two groups: one group received 400 mg of intravenous sv a...

The relatively low response rate, particularly in high peak users, raises concern about the representativeness of this study. When the higher total consumption of sumatriptan among non-respondents in this group is taken into consideration, this bias could lead to underestimation of sumatriptan overuse. Appropriate heavy use of sumatriptan for cluster headache was rare. We conclude that heavy co...

Eletriptan (Relpax, Pfizer) is one of a group of anti-migraine medications commonly referred to as 'triptans'. It is a potent serotonin agonist at the 5-HT(1B/1D) receptor and is indicated for the acute treatment of migraine headaches. Eletriptan is administered orally. It is rapidly absorbed and has a bioavailability of 50% compared to 14% for sumatriptan. The relatively high lipophilicity of ...

OBJECTIVE To evaluate the adverse events possibly caused by sumatriptan injection and explore the relationship between chest symptoms along with sumatriptan injection and coronary ischemia among Japanese patients with migraine. METHODS A cumulative total of 112 subcutaneous injections in 62 patients were evaluated. ECG was continuously monitored before and until 5 minutes after injection on 9...