Fifty patients (age range 14-65 years) with diabetes mellitus were studied; none of them had clinical evidence of chronic pancreatitis, chronic diarrhoea, or renal dysfunction. Duration of diabetes ranged from two weeks to 30 years. Patients were classified according to type of treatment: 25 were insulindependent diabetics; 15 were treated with sulphonvlureas, including two newly discovered dia...

The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the blood sugar level in dogs and rabbits compared to glibenclamide (Geisen K, Drug Res 38: 1120-1130, 1988). This cannot be explained adequately ...

OBJECTIVE To investigate the risk of incident myocardial infarction, congestive heart failure, and all cause mortality associated with prescription of oral antidiabetes drugs. DESIGN Retrospective cohort study. SETTING UK general practice research database, 1990-2005. PARTICIPANTS 91,521 people with diabetes. MAIN OUTCOME MEASURES Incident myocardial infarction, congestive heart failure...

OBJECTIVE To evaluate the efficacy of metformin against placebo, diet, oral anti-diabetics, or insulin in type 2 diabetes mellitus. DESIGN Systematic review. DATA SOURCES MEDLINE (1966-2003), EMBASE (1974-2003), LILACS (1986-2003), Cochrane library (Issue 3, 2003). SELECTION OF STUDIES 29 randomized clinical trials of metformin in monotherapy, with results on mortality, morbidity, and bio...

Maturity-onset diabetes of the young (MODY) is a rare form monogeneic that classically presents as non-insulin requiring with evidence autosomal dominant inheritance in individuals who are typically and lean. However, these criteria do not capture all cases can also overlap other types diabetes. The hepatocyte nuclear factor-1 alpha (HNF1A) mutation common cause MODY highly sensitive to sulphon...

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group – L. Hansson and others Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) – UK Prosp...

Gatifloxacin, a commonly prescribed antimicrobial can produce profound hypoglycemia and disturbances in glucose homeostasis especially in diabetes patients on sulphonylureas. Also new onset disturbances in glucose homeostasis can occur in patients who were unaffected by the previous use of gatifloxacin. Therefore it is suggested that gatifloxacin is better avoided in patients with diabetes and ...